Microduplication of 3p26.3 Implicated in Cognitive Development

Figure 2

FISH analysis of metaphase cells using two BAC probes. The fluorescent signals identify the two homologues of chromosome 3 in cells of the proband. The orange and green signals (indicated by the yellow arrow head) show hybridisation of the BAC clones RP11-203L11 and RP11-739I20, respectively, to their normal sequences. The lower homolog shows a yellow signal, created from the combination of orange and green signals (indicated by a white arrow head), which is consistent with two tandem duplications on the same homologue.