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Case Reports in Genetics
Volume 2014, Article ID 582016, 3 pages
Case Report

Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

1Department of Medical Biology and Genetics, School of Medicine, Akdeniz University, 07058 Antalya, Turkey
2Department of Hematology, School of Medicine, Akdeniz University, 07058 Antalya, Turkey

Received 9 December 2013; Accepted 15 January 2014; Published 23 February 2014

Academic Editors: D. J. Bunyan, P. D. Cotter, and A. Sazci

Copyright © 2014 Cigdem Aydin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), and extra Philadelphia chromosomes. Furthermore, a minor percentage of the patients may acquire different secondary chromosomal abnormalities including translocations between other chromosomes. We report here a patient with Ph+ CML presenting secondary chromosomal abnormalities including t(4;11)(q21;q23), t(3;3)(q29;q23) and t(11;18)(q10;q10) during the course of CML progression.