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Case Reports in Genetics
Volume 2017 (2017), Article ID 2348045, 4 pages
Case Report

Respiratory Failure due to Severe Obesity and Kyphoscoliosis in a 24-Year-Old Male with Molecularly Confirmed Prader-Willi Syndrome in Tertiary Hospital in Northern Tanzania

1Department of Internal Medicine, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Tanzania
2Department of Internal Medicine, Kilimanjaro Christian Medical University College, Tumaini University Makumira, P.O. Box 2240, Moshi, Tanzania
3Better Human Health Foundation, P.O. Box 1348, Moshi, Tanzania
4Imagedoctors International, P.O. Box 16341, Arusha, Tanzania
5Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands

Correspondence should be addressed to Elichilia R. Shao

Received 20 October 2016; Revised 20 March 2017; Accepted 4 April 2017; Published 9 April 2017

Academic Editor: Balraj Mittal

Copyright © 2017 Elichilia R. Shao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity, mild intellectual disability, hypotonia, poor sucking, cryptorchidism in males, hypogonadism, and kyphoscoliosis are common features of Prader-Willi syndrome (PWS). We report a case who had severe respiratory complications due to extreme obesity and kyphoscoliosis, which are important causes of morbidity and mortality, and discuss management. Furthermore, this is the first molecularly confirmed PWS case in Sub-Saharan Africa outside South Africa.