Case Report
Candidate Genes Associated with Delayed Neuropsychomotor Development and Seizures in a Patient with Ring Chromosome 20
Figure 2
PPI network. A list of 40 genes and gene predictions was obtained from the human assembly of February 2009 (GRCh37/hg19) (Table S12). Interaction data from STRING were used to construct networks using cytoscape software. (A) The primary network is composed of 1,572 nodes (proteins) and 54,925 edges (interactions). (B) The secondary network is composed of 794 nodes and 16,805 edges; yellow nodes are candidate proteins with data available in string (ZGPAT, HELZ2, EEF1A2, TNFRSF6B, ZBTB46, DIDO1, ARFGAP1, RTEL1, SRMS, GMEB2, YTHDF1, PTK6, GID8, BIRC7, COL9A3, COL20A1, KCNQ2, ARFRP1, and CHRNA4). (C) Cluster 2, with Ci = 40,863, is composed of 510 nodes and 10,388 edges. Nodes with green borders are considered hubs; orange are bottlenecks; and red are hub bottlenecks.