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Case Reports in Gastrointestinal Medicine
Volume 2011, Article ID 749850, 3 pages
Case Report

Two Cases of Helicobacter pylori-Negative Gastric Outlet Obstruction in Children

1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Utah and Primary Children's Medical Center, Salt Lake City, UT 84113, USA
2Digestive Diseases & Nutrition Center, Women & Children's Hospital of Buffalo, Buffalo, NY 14222, USA
3 Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's Medical Center, Hartford, CT 06106, USA

Received 8 June 2011; Accepted 4 July 2011

Academic Editors: T. S. Chen and G. Kouraklis

Copyright © 2011 Raza A. Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gastric outlet obstruction (GOO) in children is most commonly caused by idiopathic hypertrophic pyloric stenosis. Prior to proton pump inhibitors and H2 blockers, peptic ulcer disease (PUD) secondary to H. pylori was a cause of GOO. Both patients presented with a history of weight loss, vomiting, and abdominal pain. Their diagnosis of PUD and GOO was made by EGD and UGI. H. pylori testing was negative for both on multiple occasions but still received H. pylori eradication therapy. Patient 1 after failing pharmaceutical management underwent surgery for definitive treatment. Patient 2 underwent six therapeutic pyloric dilations before undergoing surgery as definitive treatment. These cases suggest that GOO secondary to PUD occurs in the absence of H. pylori infection and surgical management can provide definitive therapy.