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Case Reports in Gastrointestinal Medicine
Volume 2014 (2014), Article ID 579352, 4 pages
http://dx.doi.org/10.1155/2014/579352
Case Report

Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1

1Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY 11219, USA
2Department of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11219, USA

Received 15 March 2014; Accepted 18 June 2014; Published 1 July 2014

Academic Editor: Hideto Kawaratani

Copyright © 2014 Kenechukwu Chudy-Onwugaje et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a case of non-Hodgkin’s lymphoma (NHL) with an unusual initial manifestation as severe hypercholesterolemia and obstructive jaundice in a patient with neurofibromatosis type 1 (NF 1). NHL should be considered in the evaluation of obstructive jaundice alone or in combination with severe hypercholesterolemia. Relief of biliary obstruction led to the resolution of hypercholesterolemia in our 59-year-old male patient, followed by doxorubicin-based chemotherapy for the underlying lymphoma. NF 1 is a genetic condition that results from a defect in a tumor-suppressor gene and it is likely that this led to the development of NHL in our patient. It is important that clinicians are familiar with the gastrointestinal manifestations of NF 1, especially its association with intra-abdominal malignancies, when treating patients with a personal or family history. To the best of our knowledge, this is the first case of NHL presenting initially as severe hypercholesterolemia and it is also one of the few instances where NHL has been reported in association with NF 1.