NonHodgkin's Lymphoma with Peritoneal Localization

Curakova, E.; Genadieva-Dimitrova, M.; Misevski, J.; Caloska-Ivanova, V.; Andreevski, V.; Todorovska, B.; Isahi, U.; Trajkovska, M.; Misevska, P.; Joksimovic, N.; Genadieva-Stavric, S.; Antovic, S.; Jankulovski, N.

doi:https://doi.org/10.1155/2014/723473

Case Reports in Gastrointestinal Medicine

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Case Report | Open Access

Volume 2014 | Article ID 723473 | https://doi.org/10.1155/2014/723473

NonHodgkin's Lymphoma with Peritoneal Localization

E. Curakova,¹M. Genadieva-Dimitrova,¹J. Misevski,¹V. Caloska-Ivanova,¹V. Andreevski,¹B. Todorovska,¹U. Isahi,¹M. Trajkovska,¹P. Misevska,¹N. Joksimovic,¹S. Genadieva-Stavric,²and S. Antovic³ et al.

Academic Editor: H. Sugimura, O. I. Giouleme

Received09 Dec 2013

Accepted23 Jan 2014

Published09 Mar 2014

Abstract

The gastrointestinal tract is the most common extranodal site involved with lymphoma accounting for 5–20% of all cases. Lymphoma can occur at any site of the body, but diffuse and extensive involvement of the peritoneal cavity is unusual and rare. We report a case of diffuse large B-cell lymphoma in a 57-year-old female infiltrating the peritoneum and omentum and presenting with ascites and pleural effusion. The performed examinations did not discover any pathological findings affecting the digestive tract or parenchymal organs, except for diffuse thickening of the peritoneum and omentum. Peripheral, mediastinal, or retroperitoneal lymphadenopathy was not registered. The blood count revealed only elevated leukocytes and on examination there were no immature blood cells in the peripheral blood. The cytology from the ascites and pleural effusion did not detect any malignant cells. Due to the rapid disease progression the patient died after twenty-two days of admission. The diagnosis was discovered postmortem with the histological examination and immunohistochemical study of the material taken during the surgical laparoscopy performed four days before the lethal outcome. Although cytology is diagnostic in most cases, laparoscopy with peritoneal biopsy is the only procedure which can establish the definitive diagnosis of peritoneal lymphomatosis.

1. Introduction

Extranodal lymphoma occurs in about 40% of all patients with lymphoma and has been described in virtually every organ and tissue [1]. Extranodal disease is more common with nonHodgkin’s lymphoma (NHL); it is often intermediate- to high-grade [2, 3] and the extranodal involvement is in general a poor prognostic factor [4]. Secondary involvement of extranodal tissue as part of generalized lymphoma is significantly more common than primary extranodal disease in which there is a dominant extranodal component with no or minor nodal involvement [4]. The gastrointestinal tract is the most common extranodal site involved with lymphoma accounting for 5–20% of all cases and a gastrointestinal involvement is usually secondary to widespread nodal disease [5]. Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma are the dominant histological subtypes in extranodal lymphoma [4]. Although primary gastrointestinal lymphomas (PGLs) are relatively rare, they are still the most common type of primary extranodal lymphomas. PGL accounts for 40% of all extranodal NHLs, for 4%–20% of all NHL cases, and for about 1%–4% of all gastrointestinal malignancies [4, 6–9]. Almost 90% of the PGLs are of B cell lineage and of the nonHodgkin type [10]. Lymphoma can arise from any region of the gastrointestinal tract, but the stomach is the most commonly involved site followed by the small intestine and the ileocecal region [11].

DLBCL is the most common histological NHL subtype in adults accounting for approximately 25% of all NHL cases [12, 13]. An extranodal involvement occurs in about 40% of the DLBCLs [14, 15]. DLBCL is also the most common pathological type of gastrointestinal lymphoma in essentially all sites of the gastrointestinal tract [10] and the gastrointestinal DLBCL is the most frequent extranodal lymphoma [16]. In the Western world, nearly 90% of aggressive mature B-cell lymphomas are identified as DLBCL [17]. DLBCL is a heterogeneous disease that displays different clinical, histological, immunophenotypic, cytogenetic, and molecular features, suggesting that in fact the DLBCL spectrum includes several different disease entities [18]. Based on clinical, morphological, immunological, and genetic features the World Health Organization (WHO) divides DLBCL into many different variants, subgroups, and subtypes (Table 1) [19, 20]. Patients with DLBCL typically present with nodal (most usually cervical or abdominal) or extranodal disease and they usually exhibit rapid tumor growth and symptoms highly dependent upon the tumor localization [17]. Tumor cell origin, B symptoms, and International Prognostic index are important clinical predictors of survival in primary gastrointestinal DLBCL [21, 22]. DLBCL carries a poor prognosis and if left untreated takes an aggressive and fatal clinical course with a median survival of less than one year [23]. Despite the new treatment protocols, for certain subgroups of patients the clinical outcomes are still unsatisfactory [17].

Although lymphoma can occur at any site of the body, diffuse and extensive involvement of the peritoneal cavity is rare. Multiple intra-abdominal organ infiltration or disseminated peritoneal lymphoma, called peritoneal “lymphomatosis” (PL), receives much less attention in the literature than peritoneal carcinomatosis, probably due to its relative infrequency [24, 25]. The patterns of peritoneal involvement include smooth peritoneal thickening, discrete nodules, a diffuse infiltrative mass without symptoms of bowel obstruction, and presence of nonloculated and nonseptated exudative ascites with high protein content [4, 26, 27]. DLBCL presenting with PL is rare, but there are cases where DLBCL can occur as a form of PL without solid tumor component [28]. PL is usually associated with high-grade lymphoma and aggressive histological subtypes and it is considered to be an aggressive presentation of lymphoma [29, 30].

2. Case

A 57-year-old woman was admitted to the Clinic of Gastroenterohepatology with a two-month history of general weakness, malaise, abdominal fullness, increased abdominal gear, nausea, vomiting, and peripheral edema (Figure 1). No fever was noted before admission. She had a distended and dull abdomen without peritoneal signs and her bowel sounds were normal. There were no enlarged and palpable lymph nodes. The patient did not have significant previous medical history. Eight years ago she underwent hysterectomy with bilateral oophorectomy due to uterine myoma.Two years ago the patient had a total colonoscopy in another medical institution, but no remarkable abnormalities were found. One year ago she had a total body technetium scan which detected few accumulations in the cervical spine interpreted as lesions of degenerative origin. The peripheral blood count was initially unremarkable (hemoglobin 134 g/L, hematocrit 41%, red blood cells count /L, white blood cells count /L, and platelet count /L). During the stay the leukocyte count raised up to /L with granulocytic predominance. The peripheral blood smear showed no immature cells (80.4% neutrophils, 8.5% lymphocytes, 10.7% monocytes, 0.1% eosinophils, and 0.3% basophils). The routine laboratory tests showed no specific abnormalities, except for the remarkable LDH values of 3194 U/L (normal value: 213–423 U/L) and uric acid of 1068 μmol/L (normal value: 150–450 μmol/L). The total plasma protein level was 58 g/L, albumin level 35 g/L, globulin level 23 g/L, and CRP level 37 mg/L. Renal and liver functional tests, bilirubin, and electrolytes were normal. The serological screening for B and C hepatitis (HBsAg and anti-HCV) was negative. The abdominal ultrasound showed large amount of ascites without findings of liver cirrhosis or portal hypertension (Figure 2). The CT scan revealed diffusely thickened, nodular, and irregular peritoneum mainly affecting the upper parts of the abdomen and the anterior abdominal wall, findings which are initially consistent with peritoneal carcinomatosis. The CT scan did not indicate any tumor formation, bowel affection, or abdominal lymph node enlargement. The diagnostic paracentesis yielded chylous fluid. The LDH level in the peritoneal fluid was extremely elevated reaching values of 32585 U/L and the LDH ascites/serum ratio was 0.05. The protein level was ranging from 28 to 39 g/L, albumin level from 13 to 26 g/L, globulin level from 7 to 13 g/L, glucose level 0.2 mmol/L, cholesterol level 2 mmol/L, and triglycerides level 1.5 mmol/L. Serum-ascites albumin gradient ranged from 14 to 16 g/L. The tumor markers were also analyzed. The serum carbohydrate antigen 125 (CA 125) level was 597.9 U/mL (normal value <35.0 U/mL) and the ascites CA 125 level was elevated up to 4221 U/mL. The levels of carcinoembryonic antigen (CEA), CA 19–9 and CA 72–4 were within the normal range. The adenosine deaminase (ADA) level in ascites ranged from 67.5 U/L to 122.9 U/L and ADA ascites/serum ratio ranged from 3 to 5.91. Lysozyme level ranged from 11.2 mg/L to 20.7 mg/L. The chest radiography and thoracic ultrasound revealed small unilateral pleural effusion (Figure 3). The pleural fluid was hemorrhagic and the biochemical analysis showed LDH level of 175.8 U/L (LDH pleural fluid/serum ratio 0.05), total protein of 24.2 g/L, albumin 15.5 g/L, glucose 0.3 mmol/L, CRP 19.8 mg/L, triglycerides 0.4 mmol/L, and cholesterol level of 1.5 mmol/L. The ADA and lysozyme values in the pleural fluid were 43.4 U/L and 9.0 U/L, respectively, with pleural fluid/serum ratio of 1.95 for ADA and 0.76 for lysozyme. The tumor markers in the pleural fluid were not elevated. Because of the elevated ADA in ascites, we performed additional investigations (acid-fast staining, the Lowenstein-Jensen culture test of ascitic fluid, and the Mantoux test) in order to exclude peritoneal tuberculosis, but all these findings were negative. The gastroscopy showed few small mucosal elevations with central depression. The cytology from the peritoneal and pleural fluid did not detect any malignant cells (cytology class I) with massive coagulation necrosis, granulocytes, and macrophages in the ascitic fluid. The diagnostic laparoscopy performed by a gastroenterologist discovered only thickened peritoneum, but the histological analysis of the peritoneal biopsies did not reveal the nature of the findings. Afterwards a surgical laparoscopy was performed which also confirmed diffuse peritoneal thickening and nodular omental infiltration. During the diagnostic process the patient became febrile up to 38.5°C and she developed progressive cardiorespiratory deterioration which led to multiorgan failure and lethal outcome within twenty-two days of admission despite all symptomatic and supportive measures. The definitive diagnosis was established postmortem with the histological report from the peritoneal biopsies taken during the surgical laparoscopy four days before the lethal outcome. The preliminary histological report unexpectedly showed presence of neoplastic lymphoid cells diffusely infiltrating the fibrous and fat tissue with “starry sky” phenomenon, findings which are consistent with aggressive type of B-cell NHL (Figure 4). Afterwards, immunohistochemical study was performed and showed CD 20+ expression with proliferative fraction higher than 80% in favor of DLBCL. The patient’s family did not allow us to perform an autopsy; hence we were not able to discover any other potential lymphomatous involvement affecting other organs and tissues and to determine the disease extension and stage.

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3. Discussion

Isolated PL is a rare condition and there are only several similar case reports and autopsy reports published. Aslam presented an autopsy report of a high-grade T-cell NHL confined to the peritoneum, mesentery, omentum, and surfaces of abdominal viscera, without deeper extension into the underlying parenchyma or other primary localizations [31]. We present an unusual case of DLBCL with peritoneal lymphomatosis without other obvious primary involvements. The patient did not have any specific symptoms or physical findings and the laboratory data were inconclusive. The thickened peritoneum with deposits accompanied by elevated ascitic LDH and CA 125 strongly suggested carcinomatosis. Because of the elevated ascitic ADA, tuberculous peritonitis was also suspected, but the additional test did not confirm the diagnosis. The blood count and peripheral blood smear were almost normal and since we did not register peripheral or abdominal lymph node enlargement, we practically did not suspect any lymphoproliferative disease. The process of getting the definitive histological diagnosis in our case was difficult, complex, and time consuming. Confronting many different laboratory data that were inconsistent, confusing, and sometimes conflicting, the imaging features and the CT scan findings were the most concrete features and they served as a framework for our diagnostic process. Imaging findings showing diffusely thickened and nodular peritoneum and nodular omental infiltration with massive ascites were initially misleading towards peritoneal carcinomatosis. PL occurs less frequently than peritoneal carcinomatosis and most of the previously reported cases were also initially misdiagnosed for metastatic carcinoma [24, 28, 29, 32]. Because the omentum lacks lymphoid elements, lymphomatous omental infiltration is uncommon and the route of this dissemination is not completely clear. The presumed way of propagation is believed to be via the pathways like gastrocolic ligament, transverse mesocolon, and visceral peritoneal surface [33]. Lymphomatous omental infiltration is mostly reported in NHL and in only few Hodgkin’s lymphoma cases [34]. As many reports also suggest, patterns of tumor involvement of peritoneum, omentum, and mesentery seen in PL are mostly indistinguishable from those seen in peritoneal carcinomatosis [31, 35, 36]. PL closely mimics peritoneal carcinomatosis and it is almost impossible to differentiate peritoneal carcinomatosis from lymphomatosis based on imaging findings only, especially in cases where the peritoneal infiltration is the only evident involvement and no other findings compatible with lymphoma exist. In many of the reported cases the cytology was able to detect lymphoid cells in the peritoneal fluid and to establish the diagnosis [24, 25, 28, 37]. It seems that the cytology of ascites is a simple and usually effective method for making a diagnosis from adequate samples with time limitation [24]. However, lymphoma can evoke florid mesothelial hyperplasia which can result in a confusing cytology result and extend the diagnostic process [31, 32]. In a series of seven patients with NHL and PL, that Lynch et al. report, the cytology was diagnostic in only one patient [26]. Cases with inconclusive cytology and/or histology findings, especially when carcinoma and carcinomatosis are erroneously suspected, require laparotomy in order to establish the diagnosis [29, 30, 38]. In advanced and rapidly progressive lymphoma cases with significantly affected general condition, an unnecessary laparotomy or erroneous tumor debulking procedure may not be the best option since it can contribute to additional progression and deterioration [24, 29, 30].

It is well known that the serum LDH is elevated in many lymphoma forms and in primary gastrointestinal lymphoma the LDH level at diagnosis seems to be an independent prognostic factor [21, 39]. But despite the well-established relation between lymphoma and serum LDH, there are no clinical studies which define the relationship between PL and elevated ascites LDH levels [28]. Besides the remarkable serum LDH values of 3194 U/L, we also registered an extremely elevated ascites LDH level of 32585 U/L, much higher than in the few other PL cases [24, 28], which suggests that ascites LDH level is well elevated in PL and could be an important clue for differential diagnosis [28].

CA 125 is a mucin-like glycoprotein antigen expressed in normal tissue originally derived from celomic epithelium such as peritoneum, pleura, pericardium, fallopian tubes, and endometrium [40]. Although it can be considered to be a sensitive marker for ovarian epithelial neoplasm, it still has a limited specificity. CA 125 can be elevated in other malignancies (carcinoma of the endometrium, breast, lungs, or pancreas) or different benign conditions (endometriosis, uterine leiomyoma, cirrhosis with or without ascites, pelvic inflammatory disease, and in pleural or peritoneal fluid from any reason) [41–45]. A few studies and sporadic case reports have reported an elevated CA 125 levels in patients with low grade and in aggressive NHL [46, 47]. In most studies the serum CA 125 levels ranged from 1070 to 1400 U/mL especially in patients with effusion [46, 48]. In our patient we registered moderately elevated serum CA 125 (597.9 U/mL), but the CA 125 level in the ascites was remarkable reaching 4221 U/mL. High CA 125 level in lymphoma is associated with advanced disease stage, poor performance status, pleural or peritoneal fluid, high LDH, mediastinal and/or abdominal involvement, elevated International Prognostic Score, partial or absent response of treatment, and with decreased survival independent of the stage of the disease [40, 46, 48–50].

ADA is a purine-degrading enzyme necessary for maturation and differentiation of lymphoid cells. ADA activity of ascitic fluid has been proposed as a highly sensitive (100%) and specific (97%) nonculture method of detecting tuberculous peritonitis especially when using cut-off values from 36 to 40 IU/L [51]. Considering these values, elevated ADA in ascites of 122.9 U/L and ADA serum/ascites ratio of 5.91 in our patient raised the suspicion for specific peritonitis, but the repeated and additional tests did not confirm diagnosis. ADA can be elevated in different noninfectious conditions associated with pleural and peritoneal fluid lymphocytosis, including malignancies (adenocarcinomas, leukemias, and lymphomas) and connective tissue diseases (rheumatoid arthritis, systematic lupus erythematosus) [24, 52]. However, elevated ADA in ascites has rarely been reported in the diagnosis of lymphoma [53]. False negative and false positive ADA values are possible, and therefore an elevated ADA in ascites should be interpreted in relation to the overall clinical presentation and should not be considered equivalent to the presence of mycobacteria [52, 54].

There are only few cases in the literature where the lymphomatous involvement of the peritoneum and omentum is the only localization of lymphoma. Mostly, the peritoneal lymphomatous affection is secondary to continuous spread from some other part of the gastrointestinal tract [24, 29, 37, 38] or from abdominal lymph nodes [32, 33]. Lymphoma constitutes 15%–20% of all small intestine neoplasms and 20%–30% of all primary gastrointestinal lymphomas with ileum being the most common site (60%–65%) [10, 55]. The pattern of small-bowel involvement includes solitary or multiple nodules and circumferential wall thickening with or without aneurysmal dilatation [56, 57] and on the contrary of gastrointestinal adenocarcinoma, lymphoma is more likely to involve multiple and longer bowel segments [58]. Small bowel lymphoma mostly presents with abdominal pain, nausea, vomiting, weight loss, and bowel dysfunction (protein losing enteropathy and/or malabsorption syndrome) and less frequently with intussusceptions or gastrointestinal bleeding [37, 59, 60]. Bowel obstruction is less probable and unusual and bowel perforation is also uncommon. [56–58]. DLBCL is the most common histological subtype of NHL that occurs in large bowel with frequency ranging from 47% to 81% depending on the geographic location [61–63] and within the large bowel cecum and rectum are the most common sites. The most common symptoms are abdominal pain, weight loss, changes in bowel habits, and gastrointestinal bleeding [62–65]. Also, in more than half of the patients lymphoma is a bulky disease reaching over 5 cm in diameter [63–65] which usually makes it easily palpable by simple physical examination and detectable by abdominal ultrasound [63].

In our case, gastroscopy with biopsy excluded primary lymphoma affecting the proximal GI tract. In order to evaluate the large bowel, colonoscopy was also planned, but this was prevented by the patient’s general condition and the tendency for further deterioration. It should be emphasized that in all of the reported cases of intestinal lymphoma with diffuse peritoneal infiltration and massive ascites, the CT scans suggested some form of bowel affection [24, 29, 38, 40]. In cases of intestinal lymphoma the CT scan usually detects focal or diffuse circumferential bowel wall thickening, a stenotic bowel segment with or without aneurismal dilatation, encasement of the small-bowel wall, poor delineation at the mesenteric border, lymph node enlargement, massive tumor formation, or abdominal mass with external bowel compression [24, 26, 29, 36, 38, 40]. Our patient did not report significant bowel dysfunction symptoms and the CT scan did not detect any of the previously described radiological findings suggesting primary bowel involvement. Despite these facts, without an autopsy report, we cannot exclude a case of primary intestinal lymphoma infiltrating the peritoneum with certainty.

Primary effusion lymphoma (PEL), formerly known as “body cavity-based lymphoma,” is a rare NHL type limited to body cavities without detectable tumor formation. According to the WHO classification of hematopoietic malignancies (Table 1), PEL is classified as a distinct subtype of DLBCL and is directly and universally associated with human herpesvirus-8. Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV) have also a certain role in the pathogenesis of PEL [66]. Although most PELs occur in HIV-infected patients, several cases have been described in immunodeficient HIV-negative patients, such as in transplant recipients and patients with cancer or cirrhosis [67]. PEL is characterized by its unique predilection for serosal surfaces, including the pleura, pericardium, and peritoneum [68]. Most affected patients present with a symptomatic serous effusion containing high-grade, malignant lymphocytes and the dominant symptoms, such as dyspnea or abdominal distension, are usually related to mass effect from fluid accumulation [68]. Chest radiographs and CT scans reveal pleural and/or pericardial effusion, slight serosal thickening in absence of detectable solid mass lesion [69, 70], and parenchymal abnormalities or mediastinal enlargement [69–71]. The diagnosis of PEL is usually made on a cytological preparation of the involved effusion fluid and due to the unique liquid phase of growth of the tumor the samples are almost always positive for malignant cells [69, 71]. The malignant cells contain the genomic material from HHV-8 and the detection of the HHV-8 in the nuclei of the PEL cells is a key diagnostic criterion. The aggressive nature of PEL results in a resistance to conventional chemotherapy and poor prognosis with a short median survival of only 6 months [72]. The intense disease progression, the diagnostic delay, and the unperformed autopsy precluded additional investigations and more specific immunohistochemical and genetic analyzes in order to confirm or exclude any other potential primary lymphomatous involvement and to define the lymphoma subtype more precisely. Still, taking into account everything previously stated, PEL could also be a possible option.

4. Conclusion

Peritoneal lymphomatosis is considered a rare manifestation of aggressive histological types of high-grade lymphomas, characterized by systemic involvement and rapid clinical deterioration often rapidly leading to death. Therefore, it is extremely important to provide correct and early diagnosis in order to provide treatment and prolong survival.

In lymphoma cases surgical intervention can contribute to disease progression and additional clinical deterioration. Image-guided needle biopsy or laparoscopic peritoneal and omental biopsy appears to be the gold standard method for diagnosing PL. Therefore, they should be used in order to make the diagnosis preoperatively and every effort should be made to avoid unnecessary laparotomy or massive surgery whenever possible.

Gastrointestinal lymphoma and PL have a variable and nonspecific presentation and can resemble other neoplastic or inflammatory conditions. Clinical presentation, imaging spectrum, or laboratory data alone can be inconclusive and misinterpretations of the findings could initially presume incorrect diagnosis, extend the diagnostic process, and delay the diagnosis which reduces the possibility for optimal treatment. Therefore, only focused clinical awareness, high level of suspicion, and complementary approach can lead towards accurate diagnosis.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

References

U. Metser, O. Goor, H. Lerman, E. Naparstek, and E. Even-Sapir, “PET-CT of extranodal lymphoma,” American Journal of Roentgenology, vol. 182, no. 6, pp. 1579–1586, 2004.
View at: Google Scholar
S. J. Vinnicombe and R. H. Reznek, “Extranodal manifestations of lymphoma,” Imaging, vol. 11, no. 4, pp. 240–268, 1999.
View at: Google Scholar
A. Guermazi, P. Brice, E. de Kerviler et al., “Extranodal Hodgkin disease: spectrum of disease,” RadioGraphics, vol. 21, no. 1, pp. 161–179, 2001.
View at: Google Scholar
W. K. Lee, E. W. Lau, V. A. Duddalwar, A. J. Stanley, and Y. Y. Ho, “Abdominal manifestations of extranodal lymphoma: spectrum of imaging findings,” American Journal of Roentgenology, vol. 191, no. 1, pp. 198–206, 2008.
View at: Publisher Site | Google Scholar
C. Freeman, J. W. Berg, and S. J. Cutler, “Occurrence and prognosis of extranodal lymphomas,” Cancer, vol. 29, no. 1, pp. 252–260, 1972.
View at: Google Scholar
F. D'amore, H. Brincker, K. Gronbaek et al., “Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis,” Journal of Clinical Oncology, vol. 12, no. 8, pp. 1673–1684, 1994.
View at: Google Scholar
J. Morton, M. Leyland, G. Hudson et al., “Primary gastrointestinal non-Hodgkin's lymphoma: a review of 175 British national lymphoma investigation cases,” British Journal of Cancer, vol. 67, no. 4, pp. 776–782, 1992.
View at: Google Scholar
R. Oter, R. Bieger, P. Kluin, J. Hermans, and R. Willemze, “Primary gastrointestinal non-Hodkin's lymphoma in a population-based registry,” British Journal of Cancer, vol. 60, no. 5, pp. 745–750, 1989.
View at: Google Scholar
P. Franco, A. R. Filippi, P. Ciammella et al., “Primary duodenal follicular lymphoma: 6-years complete remission after combined radio-immunotherapy,” Acta Gastro Enterologica Belgica, vol. 74, no. 2, pp. 337–342, 2011.
View at: Google Scholar
P. Ghimire, G. Y. Wu, and L. Zhu, “Primary gastrointestinal lymphoma,” World Journal of Gastroenterology, vol. 17, no. 6, pp. 697–707, 2011.
View at: Publisher Site | Google Scholar
R. Herrmann, A. M. Panahon, M. P. Barcos, D. Walsh, and L. Stutzman, “Gastrointestinal involvement in non-Hodgkin's lymphoma,” Cancer, vol. 46, no. 1, pp. 215–222, 1980.
View at: Google Scholar
S. H. Swerdlow, E. Campo, N. L. Harris et al., Eds., World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC Press, Lyon, France, 2008.
L. M. Morton, S. S. Wang, S. S. Devesa, P. Hartge, D. D. Weisenburger, and M. S. Linet, “Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001,” Blood, vol. 107, no. 1, pp. 265–276, 2006.
View at: Publisher Site | Google Scholar
M. B. Moller, N. T. Pedersen, and B. E. Christensen, “Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation—a population-based study of 1575 cases,” British Journal of Haematology, vol. 124, no. 2, pp. 151–159, 2004.
View at: Publisher Site | Google Scholar
J. O. Armitage, P. M. Mauch, N. L. Harris, and B. P. Lymphomas, “Non-Hodgkin’s lymphomas,” in Cancer:Principles and Practice of Oncology, V. T. de Vita Jr., Ed., pp. 2256–2316, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2001.
View at: Google Scholar
F. d'amore, B. E. Christensen, H. Brincker et al., “Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas,” European Journal of Cancer, vol. 27, no. 10, pp. 1201–1208, 1991.
View at: Publisher Site | Google Scholar
U. Mey, F. Hitz, A. Lohri et al., “Diagnosis and treatment of diffuse large B-cell lymphoma,” Swiss Medical Weekly, vol. 142, Article ID w13511, 2012.
View at: Publisher Site | Google Scholar
Y. Chen, T. Han, J. Iqbal et al., “Diffuse large B-cell lymphoma in Chinese patients: immunophenotypic and cytogenetic analyses of 124 cases,” American Journal of Clinical Pathology, vol. 133, no. 2, pp. 305–313, 2010.
View at: Publisher Site | Google Scholar
E. Campo, S. H. Swerdlow, N. L. Harris, S. Pileri, H. Stein, and E. S. Jaffe, “The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications,” Blood, vol. 117, no. 19, pp. 5019–5032, 2011.
View at: Publisher Site | Google Scholar
J. J. Turner, A. M. Hughes, A. Kricker et al., “WHO non-Hodgkin's lymphoma classification by criterion-based report review followed by targeted pathology review: an effective strategy for epidemiology studies,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 9, pp. 2213–2219, 2005.
View at: Publisher Site | Google Scholar
Y. L. Yang, J. Wang, L. Z. Zhao, Z. F. Gao, H. M. Jing, and X. Y. Ke, “Clinical characteristics, cell origin and prognosis of primary gastrointestinal diffuse large B-cell lymphoma: a report of 40 cases,” Ai Zheng, vol. 27, no. 6, pp. 636–641, 2008.
View at: Google Scholar
A. M. Perry, Z. Mitrovic, and W. C. Chan, “Biological prognostic markers in diffuse large B-cell lymphoma,” Cancer Control, vol. 19, no. 3, pp. 214–226, 2012.
View at: Google Scholar
R. I. Fisher, T. P. Miller, and O. A. O'connor, “Diffuse aggressive lymphoma,” Hematology, pp. 221–236, 2004.
View at: Google Scholar
S. C. Weng and C. Y. Wu, “Lymphoma presenting as peritoneal lymphomatosis with ascites,” Journal of the Chinese Medical Association, vol. 71, no. 12, pp. 646–650, 2008.
View at: Publisher Site | Google Scholar
B. A. Runyon and J. C. Hoefs, “Peritoneal lymphomatosis with ascites: a characterization,” Archives of Internal Medicine, vol. 146, no. 5, pp. 887–888, 1986.
View at: Google Scholar
M. A. Lynch, K. C. Cho, R. B. Jeffrey Jr., D. D. Alterman, and M. P. Federle, “CT of peritoneal lymphomatosis,” American Journal of Roentgenology, vol. 151, no. 4, pp. 713–715, 1988.
View at: Google Scholar
D. L. Angela, C. S. Janet, and H. S. Mcleslie, “Secondary tumors and tumor like lesions of the peritoneal cavity: imaging features with pathologic correlation,” RadioGraphics, vol. 29, no. 2, pp. 347–373, 2009.
View at: Google Scholar
Y. G. Kim, J. Y. Baek, S. Y. Kim et al., “Peritoneal lymphomatosis confounded by prior history of colon cancer: a case report,” BMC Cancer, vol. 11, article 276, 2011.
View at: Publisher Site | Google Scholar
M. Horger, M. Muller-Schimpfle, I. Yirkin, M. Wehrmann, and C. D. Claussen, “Extensive peritoneal and omental lymphomatosis with raised CA 125 mimicking carcinomatosis: CT and intraoperative findings,” British Journal of Radiology, vol. 77, no. 913, pp. 71–73, 2004.
View at: Publisher Site | Google Scholar
M. P. Ridolfini, P. Caprino, S. Berardi et al., “A very advanced case of a T cell peritoneal lymphomatosis,” Annali Italiani di Chirurgia, vol. 83, no. 1, pp. 71–73, 2012.
View at: Google Scholar
M. B. Aslam, “Peritoneal lymphomatosis, a morphological look alike to peritoneal carcinomatosis: an autopsy report,” Journal of Clinical Pathology, vol. 62, no. 5, article 480, 2009.
View at: Publisher Site | Google Scholar
N. Hazarika, B. Dhabhar, and T. K. Saikia, “Highly elevated serum CA 125 in a lady with ascites and retroperitoneal mass—a diagnostic dilemma,” Journal of Association of Physicians of India, vol. 56, pp. 47–48, 2008.
View at: Google Scholar
M. I. Sharifah, N. A. Zamzami, and T. N. Rafeah, “Diffuse peritoneal lymphomatosis simulating peritoneal carcinomatosis,” Medical Journal of Malaysia, vol. 66, no. 3, pp. 270–272, 2011.
View at: Google Scholar
J. E. Jacobs, K. E. Salhany, K. R. Fox, and B. A. Birnbaum, “Omental caking in Hodgkin's disease. Computed tomography findings,” Clinical Imaging, vol. 20, no. 4, pp. 253–255, 1996.
View at: Publisher Site | Google Scholar
P. Goodman and B. Raval, “Omental cakes in American Burkitt lymphoma: computed tomography demonstration,” Clinical Imaging, vol. 13, no. 2, pp. 117–118, 1989.
View at: Google Scholar
Y. Kim, O. Cho, S. Song, H. Lee, H. Rhim, and B. Koh, “Peritoneal lymphomatosis: CT findings,” Abdominal Imaging, vol. 23, no. 1, pp. 87–90, 1998.
View at: Publisher Site | Google Scholar
Y. Tsutsumi, K. I. Inada, K. Morita, and T. Suzuki, “T-cell lymphomas diffusely involving the intestine: report of two rare cases,” Japanese Journal of Clinical Oncology, vol. 26, no. 4, pp. 264–272, 1996.
View at: Google Scholar
Y. N. Lin, J. W. Chou, P. H. Chuang, K. S. Cheng, C. Y. Peng, and I. P. Chiang, “Primary small intestinal natural killer/T cell lymphoma mimicking tuberculous peritonitis: report of a case and review of the literature,” Internal Medicine, vol. 50, no. 5, pp. 515–518, 2011.
View at: Publisher Site | Google Scholar
G. Fasola, R. Fanin, F. Gherlinzoni et al., “Serum LDH concentration in non-Hodgkin's lymphomas. Relationship to histologic type, tumor mass, and presentation features,” Acta Haematologica, vol. 72, no. 4, pp. 231–238, 1984.
View at: Google Scholar
O. Bairey, D. Blickstein, P. Stark et al., “Serum CA 125 as a prognostic factor in non-Hodgkin's lymphoma,” Leukemia & Lymphoma, vol. 44, no. 10, pp. 1733–1738, 2003.
View at: Publisher Site | Google Scholar
B. W. Mol, N. Bayram, J. G. Lijmer et al., “The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis,” Fertility and Sterility, vol. 70, no. 6, pp. 1101–1108, 1998.
View at: Publisher Site | Google Scholar
E. Zuckerman, A. Lanir, E. Sabo et al., “Cancer antigen 125: a sensitive marker of ascites in patients with liver cirrhosis,” American Journal of Gastroenterology, vol. 94, no. 6, pp. 1613–1618, 1999.
View at: Publisher Site | Google Scholar
H. Devarbhavi, D. Kaese, A. W. Williams, J. Rakela, G. G. Klee, and P. S. Kamath, “Cancer antigen 125 in patients with chronic liver disease,” Mayo Clinic Proceedings, vol. 77, no. 6, pp. 538–541, 2002.
View at: Google Scholar
K. Sjövall, B. Nilsson, and N. Einhorn, “The significance of serum CA 125 elevation in malignant and nonmalignant diseases,” Gynecologic Oncology, vol. 85, no. 1, pp. 175–178, 2002.
View at: Publisher Site | Google Scholar
O. Topalak, U. Saygili, M. Soyturk et al., “Serum, pleural effusion, and ascites CA-125 levels in ovarian cancer and nonovarian benign and malignant diseases: a comparative study,” Gynecologic Oncology, vol. 85, no. 1, pp. 108–113, 2002.
View at: Publisher Site | Google Scholar
J. Zidan, O. Hussein, W. Basher, and S. Zohar, “Serum CA125: a tumor marker for monitoring response to treatment and follow-up in patients with non-Hodgkin's lymphoma,” The Oncologist, vol. 9, no. 4, pp. 417–421, 2004.
View at: Publisher Site | Google Scholar
L. Benboubker, “A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels,” Annals of Oncology, vol. 11, no. 11, pp. 1485–1491, 2000.
View at: Google Scholar
M. Lazzarino, “Serum CA 125 is of clinical value in the staging and follow up of patient with non-Hodgkin’s lymphoma,” Cancer, vol. 82, pp. 576–582, 2000.
View at: Google Scholar
C. Bonnet, Y. Beguin, F. Fassotte, L. Seidel, F. Luyckx, and G. Fillet, “Limited usefulness of CA125 measurement in the management of Hodgkin's and non-Hodgkin's lymphoma,” European Journal of Haematology, vol. 78, no. 5, pp. 399–404, 2007.
View at: Publisher Site | Google Scholar
I. D. Zacharos, S. P. Efstathiou, E. Petreli et al., “The prognostic significance of CA 125 in patients with non-Hodgkin's lymphoma,” European Journal of Haematology, vol. 69, no. 4, pp. 221–226, 2002.
View at: Publisher Site | Google Scholar
A. Riquelme, M. Calvo, F. Salech et al., “Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis: a meta-analysis,” Journal of Clinical Gastroenterology, vol. 40, no. 8, pp. 705–710, 2006.
View at: Publisher Site | Google Scholar
R. Laniado-Laborin, “Adenosine deaminase in the diagnosis of tuberculous pleural effusion: is it really an ideal test? A word of caution,” Chest, vol. 127, no. 2, pp. 417–418, 2005.
View at: Publisher Site | Google Scholar
M. Buyukberber, A. Sevinc, C. E. Cagliyan, M. T. Gulsen, I. Sari, and C. Camci, “Non-Hodgkin lymphoma with high adenosine deaminase levels mimicking peritoneal tuberculosis: an unusual presentation,” Leukemia & Lymphoma, vol. 47, no. 3, pp. 565–568, 2006.
View at: Publisher Site | Google Scholar
Y. Ogat, K. Aoe, A. Hiraki et al., “Is adenosine deaminase in pleural fluid a useful marker for differentiating tuberculosis from lung cancer or mesothelioma in Japan, a country with intermediate incidence of tuberculosis?” Acta Medica Okayama, vol. 65, no. 4, pp. 259–263, 2011.
View at: Google Scholar
D. Schottenfeld, J. L. Beebe-Dimmer, and F. D. Vigneau, “The epidemiology and pathogenesis of neoplasia in the small intestine,” Annals of Epidemiology, vol. 19, no. 1, pp. 58–69, 2009.
View at: Publisher Site | Google Scholar
M. S. Levine, S. E. Rubesin, L. Pantongrag-Brown, J. L. Buck, and H. Herlinger, “Non-Hodgkin's lymphoma of the gastrointestinal tract: radiographic findings,” American Journal of Roentgenology, vol. 168, no. 1, pp. 165–172, 1997.
View at: Google Scholar
E. J. Balthazar, M. Noordhoorn, A. J. Megibow, and R. B. Gordon, “CT of small-bowel lymphoma in immunocompetent patients and patients with AIDS: comparison of findings,” American Journal of Roentgenology, vol. 168, no. 3, pp. 675–680, 1997.
View at: Google Scholar
S. Ghai, J. Pattison, S. Ghai, M. E. O'Malley, K. Khalili, and M. Stephens, “Primary gastrointestinal lymphoma: spectrum of imaging findings with pathologic correlation,” RadioGraphics, vol. 27, no. 5, pp. 1371–1388, 2007.
View at: Publisher Site | Google Scholar
B. Li, Y. K. Shi, X. H. He et al., “Primary non-Hodgkin lymphomas in the small and large intestine: clinicopathological characteristics and management of 40 patients,” International Journal of Hematology, vol. 87, no. 4, pp. 375–381, 2008.
View at: Publisher Site | Google Scholar
J. C. Gonzalez-Vitale, L. G. Gomez, and R. M. Goldblum, “Immunoblastic lymphoma of small intestine complicating late-onset immunodeficiency,” Cancer, vol. 49, no. 3, pp. 445–449, 1982.
View at: Google Scholar
G. Stanojević, M. Stojanović, M. Jovanović et al., “Primary colorectal lymphomas,” Vojnosanitetski Pregled, vol. 66, no. 4, pp. 295–301, 2009.
View at: Publisher Site | Google Scholar
S. Cai, F. Cannizzo Jr., K. M. Bullard Dunn, J. F. Gibbs, M. Czuczman, and A. Rajput, “The role of surgical intervention in non-Hodgkin's lymphoma of the colon and rectum,” American Journal of Surgery, vol. 193, no. 3, pp. 409–412, 2007.
View at: Publisher Site | Google Scholar
O. Bairey, R. Ruchlemer, and O. Shpilberg, “Non-Hodgkin's lymphomas of the colon,” Israel Medical Association Journal, vol. 8, no. 12, pp. 832–835, 2006.
View at: Google Scholar
G. Z. Stanojević, M. P. Stojanović, M. M. Stojanović et al., “Non-Hodgkin’s lymphomas of the large bowel-clinical characteristics, prognostic factors and survival,” Acta Chirurgica Iugoslavica, vol. 55, pp. 109–114, 2008.
View at: Publisher Site | Google Scholar
C. W. Fan, C. R. Changchien, J. Y. Wang et al., “Primary colorectal lymphoma,” Diseases of the Colon and Rectum, vol. 43, no. 9, pp. 1277–1282, 2000.
View at: Google Scholar
P. M. Banks and R. A. Warnke, “Primary effusion lymphoma,” in Tumours of Haematopoietic and Lymphoid Tissues: World Health Organization Classification of Tumours, E. S. Jaffe, N. L. Harris, H. Stein, and J. W. Vardium, Eds., pp. 179–180, IARC Press, Lyon, France, 2001.
View at: Google Scholar
A. Carbone and A. Gloghini, “PEL and HHV8-unrelated effusion lymphomas : classification and diagnosis,” Cancer, vol. 114, no. 4, pp. 225–227, 2008.
View at: Publisher Site | Google Scholar
Y. B. Chen, A. Rahemtullah, and E. Hochberg, “Primary effusion lymphoma,” Oncologist, vol. 12, no. 5, pp. 569–576, 2007.
View at: Publisher Site | Google Scholar
R. G. Nador, E. Cesarman, A. Chadburn et al., “Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus,” Blood, vol. 88, no. 2, pp. 645–656, 1996.
View at: Google Scholar
D. S. Karcher and S. Alkan, “Human herpesvirus-8-associated body cavity-based lymphoma in human immunodeficiency virus-infected patients: a unique B-cell neoplasm,” Human Pathology, vol. 28, no. 7, pp. 801–808, 1997.
View at: Publisher Site | Google Scholar
S. Morassut, E. Vaccher, L. Balestreri et al., “HIV-associated human herpesvirus 8-positive primary lymphomatous effusions: radiologic findings in six patients,” Radiology, vol. 205, no. 2, pp. 459–463, 1997.
View at: Google Scholar
E. Boulanger, L. Gerard, J. Gabarre et al., “Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS,” Journal of Clinical Oncology, vol. 23, no. 19, pp. 4372–4380, 2005.
View at: Publisher Site | Google Scholar

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Copyright © 2014 E. Curakova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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