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Case Reports in Gastrointestinal Medicine
Volume 2015 (2015), Article ID 405238, 3 pages
Case Report

Cannabinoid Hyperemesis Syndrome: A Paradoxical Cannabis Effect

1Internal Medicine Program, Department of Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA
2Department of Gastroenterology, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA

Received 6 April 2015; Revised 9 June 2015; Accepted 16 June 2015

Academic Editor: Stephanie Van Biervliet

Copyright © 2015 Ivonne Marie Figueroa-Rivera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite well-established antiemetic properties of marijuana, there has been increasing evidence of a paradoxical effect in the gastrointestinal tract and central nervous system, given rise to a new and underrecognized clinical entity called the Cannabinoid Hyperemesis Syndrome. Reported cases in the medical literature have established a series of patients exhibiting a classical triad of symptoms: cyclic vomiting, chronic marijuana use, and compulsive bathing. We present a case of a 29-year-old man whose clinical presentation strongly correlates with cannabinoid hyperemesis syndrome. Despite a diagnosis of exclusion, this syndrome should be considered plausible in the setting of a patient with recurrent intractable vomiting and a strong history of cannabis use as presented in this case.