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Case Reports in Gastrointestinal Medicine
Volume 2016, Article ID 2861086, 3 pages
Case Report

Gastric and Duodenal Pseudomelanosis: An Extended Unusual Finding in a Patient with End Stage Kidney Disease

1Division of Gastroenterology and Hepatology, University of California San Francisco (UCSF), 1st Floor, Endoscopy Suite, 2823 Fresno Street, Fresno, CA 93721, USA
2University of Nevada, 1155 Mill Street, Reno, NV 89502, USA

Received 29 November 2015; Revised 6 February 2016; Accepted 8 February 2016

Academic Editor: Hideto Kawaratani

Copyright © 2016 Noor Ul Ain Qureshi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gastric and duodenal pseudomelanosis is a rare endoscopic mucosal finding, characterized by the accumulation of iron in macrophages of the lamina propria of the stomach and duodenum. The clinical significance and long term sequelae have not been clarified yet. However, this benign condition is associated with a variety of clinical conditions, such as essential hypertension, chronic renal failure, diabetes mellitus, long term intake of iron supplements, and furosemide. Duodenal pseudomelanosis appears to be more common than gastric pseudomelanosis given the fact that a few cases of gastric pseudomelanosis have been reported in the literature so far. We report a case of 88-year-old lady with ESRD who is maintained on hemodialysis and presented with abdominal pain. An upper GI endoscopy showed discoloration of the antrum of the stomach and most portion of her duodenum. Histopathology report confirmed the presence of iron laden macrophages in the lamina propria of both stomach and duodenum.