Case Reports in Gastrointestinal Medicine

Case Reports in Gastrointestinal Medicine / 2017 / Article

Case Report | Open Access

Volume 2017 |Article ID 5879374 |

Mouhanna Abu Ghanimeh, Ayman Qasrawi, Omar Abughanimeh, Sakher Albadarin, John H. Helzberg, "Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding", Case Reports in Gastrointestinal Medicine, vol. 2017, Article ID 5879374, 6 pages, 2017.

Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding

Academic Editor: Naohiko Koide
Received17 May 2017
Revised12 Jul 2017
Accepted27 Jul 2017
Published29 Aug 2017


Renal cell carcinoma (RCC) accounts for 80–85% of all primary renal neoplasms. Although RCC can metastasize to any organ, gastric metastases from RCC are exceedingly rare. A 67-year-old male presented with melena and acute blood loss anemia. The patient had a history of RCC that had been treated with a radical nephrectomy. He had a recent myocardial infarction and was receiving double antiplatelet therapy. After hemodynamic stabilization, esophagogastroduodenoscopy showed a polypoid mass in the gastric fundus. The mass was excised. Histological and immunohistochemical evaluation were consistent with clear cell RCC. The polypoid lesion is consistent with a late solitary metastasis.

1. Introduction

Renal cell carcinoma (RCC) is the most common cancer originating from the kidney [1]. Lungs, bones, liver, and brain are the most common sites of RCC metastasis [2, 3]. Uncommon metastatic sites, including the gastrointestinal tract [24], have also been reported. Gastric metastasis from RCC is rare [5, 6]. Gastric metastases are typically asymptomatic, single, and located in the gastric body or fundus [5, 6]. If they are symptomatic, then gastrointestinal bleeding and anemia are the most common presentations [5, 6]. RCC has the potential for late solitary metastasis. Isolated gastric metastasis from RCC can occur up to 20 years after radical nephrectomy [7]. Immunohistochemistry is useful and increasingly utilized in the diagnosis of RCC [8, 9]. The prognosis in patients with metastatic RCC is generally poor, with a five-year survival rate of 5–30% [10]. Treatment options include embolization and epinephrine injection for bleeding and endoscopic resection or surgery [1116]. Surgical resection remains the best therapeutic option for a solitary gastric metastasis, resulting in significant survival prolongation in eligible patients [8].

2. Case Summary

A 67-year-old man presented with multiple episodes of melena. His past medical history involved polycystic kidney disease, live donor renal transplantation in 2002 with chronic immunosuppression, and metastatic left-sided RCC that had been treated with radical nephrectomy and the resection of a pulmonary metastasis in 2014. The patient had chronic kidney disease, stage 3, and a recent ST segment elevation myocardial infarction with percutaneous coronary intervention and drug eluting stent insertion. The patient was on 81 mg of aspirin daily and 90 mg of ticagrelor twice daily.

His vital signs on presentation were blood pressure of 121/82 mmHg, pulse of 105 bpm, and oral temperature of 97.7°F (36.5 C). On physical examination, the patient was pale and in mild distress. Abdominal and cardiopulmonary exams were unremarkable. Initial laboratory evaluation included a hemoglobin (Hb) level of 8.8 g/dl (normal: 13.5–17.5 g/dl), white blood cell (WBC) count of 11,300/cmm (normal: 4,000–11,000/cmm), platelet count of 344,000 cmm (normal: 150,000–450,000/cmm), serum creatinine level of 2.3 mg/dl (normal: 0.9–1.2 mg/dl), aspartate aminotransferase level of 27 units/L (normal: 15–46 units/L), alanine aminotransferase level of 14 units/L (normal: 13–69 units/L), alkaline phosphatase level of 117 units/L (normal: 42–140 units/L), and international normalized ratio of 1.2. The patient was admitted for stabilization and further evaluation of gastrointestinal bleeding.

The patient was intravenously given 80 mg pantoprazole, followed by 8 mg/hour continuous infusion. A total of 2 units of packed red blood cells were transfused. Aspirin and ticagrelor were initially held. On hospitalization day 1, the patient was hemodynamically stable and his Hb level increased to 9.9 g/dl after transfusion. The gastroenterology service proceeded with esophagogastroduodenoscopy (EGD). The EGD (Figure 1) showed a 2.5 to 3.0 cm polypoid mass in the gastric fundus. The polyp was completely removed with a polypectomy snare and cautery. Bleeding occurred after polyp removal, and hemostasis was achieved via local epinephrine injection and the application of two Cook hemostasis clips.

The histological examination (Figure 2) demonstrated a submucosal tumor comprising nests and fascicles of cells with abundant clear cytoplasm and moderately pleomorphic nuclei with prominent eosinophilic nucleoli. A background vascular network and acute and chronic inflammation were observed. Immunohistochemical staining (Figure 3) was positive for pan-keratin PAX2 and PAX8. Both the morphology and immune phenotypes were most consistent with metastatic clear cell RCC, comparable with the right lung lesion resected in 2014.

The patient was observed overnight in the intensive care unit. His Hb levels were unchanged, and he remained hemodynamically stable. Aspirin and ticagrelor treatments were resumed. The oncology service decided to follow him as an outpatient. Chemotherapy was not initiated with his recent gastrointestinal blood loss and myocardial infarction. He is following up now with the oncology and cardiology clinics and has been doing well about 1 year after his presentation.

3. Discussion

RCC is the most common cancer originating from the kidney. This cancer is responsible for 80 to 85% of all primary renal neoplasms and accounts for 3% of all adult malignancies [1]. RCC has an abundant blood supply and can metastasize to any organ [2, 3]. The most common sites of metastasis include the lungs, bones, liver, and brain [2, 3]. However, RCCs can also metastasize to unusual sites, including the pancreas, thyroid gland, adrenal gland, skeletal muscle, and skin [4]. Studies have reported that a metastasis is detected in approximately 30% of RCC patients on initial presentation [3].

Gastric metastases from RCC are exceedingly rare [5, 6]. Pollheimer et al. [5] reported 5 patients who developed gastric metastases from an Austrian database of 2,082 RCC patients. In one instance, an isolated gastric metastasis from RCC was reported 20 years after radical nephrectomy [7]. Table 1 summarizes the reported cases of gastric metastases from RCC in English literature.

Case and referenceAge (years), sexGastrointestinal symptomsLocationGross appearanceHistologyTreatment

Sullivan et al. 1980 [17]69, maleBleedingAntrumMass, singleNot specifiedAntrectomy
Boruchowicz et al. 1995 [18]48, maleDysphagiaFundusPolypoid, singleClear cellChemotherapy
Blake et al. 1995 [11]63, maleBleedingNot specifiedNot specifiedNot specifiedEmbolization
Odori et al. 1998 [19]58, maleNot specifiedNot specifiedUlcerated, singleClear cellTotal gastrectomy with regional lymph node dissection
Picchio et al. 2000 [12]64, femaleBleedingBodyPolyp, singleClear cellSubtotal gastrectomy
Mascarenhas et al. 2001 [20]66, maleBleedingBodyUlcerated, singleClear cellPartial gastrectomy
Kobayashi et al. 2004 [21]78, maleAnemiaLower one-third of stomachMass, singleNot specifiedGastrectomy
Kok Wee et al. 2004 [7]60, maleBleedingBody2 lesions, protruding and ulceratedClear cellEndoscopic therapy
Lamb et al. 2005 [13]69, maleBleedingBodyMass, singleClear cellEmbolization, octreotide
Riviello et al. 2006 [22]68, maleBleedingFundusMass, singleClear cellTotal gastrectomy, chemotherapy
Pezzoli et al. 2007 [15]78, maleAnemiaBodyPolyps, multipleClear cellEndoscopic mucosal resection
Saidi and Remine 2007 [23]Not specifiedBleedingBodyPolyp, singleClear cellWedge resection
Pollheimer et al. 2008 [5]69, maleEpigastric pain, Nausea, vomitingBodyMass, singleClear cellTamoxifen
Pollheimer et al. 2008 [5]77, maleNo symptomsAntrumUlcerated, singleClear cellInterferon
Pollheimer et al. 2008 [5]83, femaleBleedingAntrumMass, multipleClear cellEndoscopic therapy, interferon
Pollheimer et al. 2008 [5]65, femaleBleedingNot specifiedMultipleClear cellEndoscopic therapy
Pollheimer et al. 2008 [5]69, maleAnemia, epigastric painBodyMultipleClear cellEndoscopic therapy, sunitinib
Kibria et al. 2009 [24]53, maleBleedingFundusPolypoid, singleClear cellNone
Yamamoto et al. 2009 [8]74, maleBleedingBodyPolypoid, singleNot specifiedWedge resection
Tiwari et al. 2010 [25]58, femaleBleedingAntrumPolypoid, singleClear cellSubtotal gastrectomy
García-Campelo et al. 2010 [26]75, maleNo symptomsFundus and bodyPolypoid, multipleNot specifiedSunitinib
Sugasawa et al. 2010 [27]69, maleAnemiaFundusUlcerated, singleClear cellWedge resection
Eslick and Kalantar 2011 [28]65, maleBleedingLower stomachPolypoid, singleClear cellPolypectomy
Kim et al. 2012 [29]79, maleAbdominal painBodyErosive, singleClear cellPartial gastrectomy
Xu et al. 2012 [30]60, maleAnemiaBodyPolyp, multipleClear cellPolypectomy, sunitinib, sorafenib
Siriwardana et al. 2012 [31]71, maleAnemiaNot specifiedPolypoid, singleClear cellEndoscopic mucosal resection
Namikawa et al. 2012 [32]65, maleNot specifiedBodyPolypoid, singleClear cellWedge resection
Rodrigues et al. 2012 [33]45, femaleBleedingBodyUlcerated, singleNot specifiedSunitinib
Chibbar et al. 2013 [34]69, femaleAnemiaBodyPolypoid, singleClear cellEndoscopic mucosal resection
Rita et al. 2014 [6]77, maleBleeding, abdominal painBodyPolypoid, singleClear cellEndoscopic resection
Greenwald et al. 2014 [35]62, maleNo symptomsFundusMass, singleClear cellPartial gastrectomy
Costa et al. 2014 [36]66, femaleAnemiaBodyUlcerated, singleNot specifiedLaparoscopic wedge resection
Kumcu et al. 2014 [37]59, maleBleeding, weight lossBodyPolypoid, singleClear cellPartial gastrectomy
Sakurai et al. 2014 [38]62, maleBleeding, anemiaBodyMass, singleClear cellPartial gastrectomy
Forman et al. 2015 [39]76, femaleBleeding, anemiaCardiaMass, singleClear cellNot specified
Kongnyuy et al. 2016 [40]68, maleAnemia, bleedingFundusMass, singleClear cellNot specified
Our case 201667, maleBleedingFundusPolypoid, singleClear cellPolypectomy, plan for chemotherapy

Most RCC gastric metastases are located in the gastric body and fundus. Single tumors predominate over multiple tumors [6]. Histologically, these metastases are situated in the submucosa [3, 12]. Clear cell histology is the predominant form of RCC. The presence of clear cell morphology in any unknown lesion should prompt the pathologist to consider the possibility of metastatic RCC, even in the absence of a prior diagnosis [30]. Endoscopically, the metastasis typically appears as a polypoid submucosal-like tumor with a central depression.

In general, the outcome with metastatic RCC is poor with 5-year survival rates of 5–30% [10]. Patients with a single metastasis fare better than those with multiple metastases.

Immunohistochemistry, particularly for vimentin and PAX-2, is a useful adjunct in the diagnosis of RCC [8, 9]. Vimentin is an intermediate filament protein expressed in normal renal tissues [8], and PAX-2 is a transcription factor required for the development and proliferation of renal tubules [9]. Both proteins are expressed in 85% of metastatic clear cell RCCs [8, 9].

Informed consent was obtained from the patient to publish the details of this case report.


This manuscript is a detailed description of a previous abstract which was presented at the annual meeting of the American College of Gastroenterology (ACG) 2016 in Las Vegas and it was published as an abstract in a special supplement of the American Journal of Gastroenterology.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Authors’ Contributions

Mouhanna Abu Ghanimeh, Ayman Qasrawi, and Omar Abughanimeh wrote and revised the manuscript. Sakher Albadarin edited the manuscript. John H. Helzberg performed the EGD, provided images, and reviewed and edited the final manuscript.


  1. R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2016,” CA: A Cancer Journal for Clinicians, vol. 66, no. 1, pp. 7–30, 2016. View at: Publisher Site | Google Scholar
  2. J. D. Maldazys and J. B. deKernion, “Prognostic factors in metastatic renal carcinoma,” Journal of Urology, vol. 136, no. 2, pp. 376–379, 1986. View at: Google Scholar
  3. Y. Satomi, Y. Senga, M. Nakahashi et al., “A clinical and statistical study of 333 cases of renal cell carcinoma. III. Operations, operative findings and results,” Nihon Hinyokika Gakkai Zasshi, vol. 78, no. 8, pp. 1394–1402, 1987. View at: Google Scholar
  4. V. T. DeVita, T. S. Lawrence, and S. A. Rosenberg, Cancer: Principles and Practice of Oncology, Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 8th edition, 2008.
  5. M. J. Pollheimer, T. A. Hinterleitner, V. S. Pollheimer, A. Schlemmer, and C. Langner, “Renal cell carcinoma metastatic to the stomach: Single-centre experience and literature review,” BJU International, vol. 102, no. 3, pp. 315–319, 2008. View at: Publisher Site | Google Scholar
  6. H. Rita, A. Isabel, C. Iolanda et al., “Treatment of gastric metastases from renal cell carcinoma with endoscopic therapy,” Clinical Journal of Gastroenterology, vol. 7, no. 2, pp. 148–154, 2014. View at: Publisher Site | Google Scholar
  7. L. Kok Wee, R.-Y. Shyu, L.-F. Sheu, T.-Y. Hsieh, J.-C. Yan, and P.-J. Chen, “Metastatic renal cell cancer,” Gastrointestinal Endoscopy, vol. 60, no. 2, p. 265, 2004. View at: Publisher Site | Google Scholar
  8. D. Yamamoto, Y. Hamada, S. Okazaki et al., “Metastatic gastric tumor from renal cell carcinoma,” Gastric Cancer, vol. 12, no. 3, pp. 170–173, 2009. View at: Publisher Site | Google Scholar
  9. N. Gokden, M. Gokden, D. C. Phan, and J. K. McKenney, “The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: An immunohistochemical study with comparison to renal cell carcinoma marker,” American Journal of Surgical Pathology, vol. 32, no. 10, pp. 1462–1467, 2008. View at: Publisher Site | Google Scholar
  10. S. C. Campbell and C. N. Andrew, “Renal tumours,” in Campbell-Walsh Urology, pp. 1582–1605, Sounders Elsevier Pub, 9th edition, 2007. View at: Google Scholar
  11. M. A. Blake, A. Owens, D. P. O'Donoghue, and D. P. MacErlean, “Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: Report of three cases,” Gut, vol. 37, no. 6, pp. 835–837, 1995. View at: Publisher Site | Google Scholar
  12. M. Picchio, A. Paioletti, E. Santini et al., “Gastric metastasis from renal cell carcinoma fourteen years after radical nephrectomy,” Acta Chirurgica Belgica, vol. 100, no. 5, pp. 228–230, 2000. View at: Google Scholar
  13. G. W. A. Lamb, J. Moss, R. Edwards, and M. Aitchison, “Case Report: Octreotide as an adjunct to embolisation in the management of recurrent bleeding upper gastrointestinal metastases from primary renal cell cancer,” International Urology and Nephrology, vol. 37, no. 4, pp. 691–693, 2005. View at: Publisher Site | Google Scholar
  14. P. H. Patel, R. S. K. Chaganti, and R. J. Motzer, “Targeted therapy for metastatic renal cell carcinoma,” British Journal of Cancer, vol. 94, no. 5, pp. 614–619, 2006. View at: Publisher Site | Google Scholar
  15. A. Pezzoli, V. Matarese, S. Boccia, L. Simone, and S. Gullini, “Gastrointestinal bleeding from gastric metastasis of renal cell carcinoma, treated by endoscopic polypectomy.,” Endoscopy, vol. 39, p. E52, 2007. View at: Publisher Site | Google Scholar
  16. T. Klatte, N. Kroeger, U. Zimmermann, M. Burchardt, A. S. Belldegrun, and A. J. Pantuck, “The contemporary role of ablative treatment approaches in the management of renal cell carcinoma (RCC): Focus on radiofrequency ablation (RFA), high-intensity focused ultrasound (HIFU), and cryoablation,” World Journal of Urology, vol. 32, no. 3, pp. 597–605, 2014. View at: Publisher Site | Google Scholar
  17. W. G. Sullivan, E. B. Cabot, and R. E. Donohue, “Metastatic renal cell carcinoma to stomach,” Urology, vol. 15, no. 4, pp. 375–378, 1980. View at: Publisher Site | Google Scholar
  18. A. Boruchowicz, P. Desreumaux, V. Maunoury et al., “Dysphagia revealing esophageal and gastric metastases of renal carcinoma,” The American Journal of Gastroenterology, vol. 90, no. 12, pp. 2263-2264, 1995. View at: Google Scholar
  19. T. Odori, Y. Tsuboi, K. Katoh et al., “A solitary hematogenous metastasis to the gastric wall from renal cell carcinoma four years after radical nephrectomy,” Journal of Clinical Gastroenterology, vol. 26, no. 2, pp. 153-154, 1998. View at: Publisher Site | Google Scholar
  20. B. Mascarenhas, B. Konety, and J. T. Rubin, “Recurrent metastatic renal cell carcinoma presenting as a bleeding gastric ulcer after a complete response to high-dose interleukin-2 treatment,” Urology, vol. 57, article 168, no. 1, 2001. View at: Google Scholar
  21. O. Kobayashi, H. Murakami, T. Yoshida et al., “Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center,” World Journal of Surgery, vol. 28, no. 6, pp. 548–551, 2004. View at: Google Scholar
  22. C. Riviello, I. Tanini, G. Cipriani et al., “Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature,” World Journal of Gastroenterology, vol. 12, no. 32, pp. 5234–5236, 2006. View at: Google Scholar
  23. R. F. Saidi and S. G. Remine, “Isolated gastric metastasis from renal cell carcinoma 10 years after radical nephrectomy [4],” Journal of Gastroenterology and Hepatology (Australia), vol. 22, no. 1, pp. 143-144, 2007. View at: Publisher Site | Google Scholar
  24. R. Kibria, K. Sharma, S. A. Ali, and P. Rao, “Upper gastrointestinal bleeding revealing the stomach metastases of renal cell carcinoma,” Journal of Gastrointestinal Cancer, vol. 40, no. 1-2, pp. 51–54, 2009. View at: Publisher Site | Google Scholar
  25. P. Tiwari, A. Tiwari, M. Vijay et al., “Upper gastro-intestinal bleeding - rare presentation of renal cell carcinoma,” Urology Annals, vol. 2, no. 3, pp. 127–129, 2010. View at: Google Scholar
  26. R. García-Campelo, M. Quindós, D. Dopico Vázquez et al., “Renal cell carcinoma: Complete pathological response in a patient with gastric metastasis of renal cell carcinoma,” Anti-Cancer Drugs, vol. 21, no. 1, pp. S13–S15, 2010. View at: Publisher Site | Google Scholar
  27. H. Sugasawa, T. Ichikura, S. Ono et al., “Isolated gastric metastasis from renal cell carcinoma 19 years after radical nephrectomy,” International Journal of Clinical Oncology, vol. 15, no. 2, pp. 196–200, 2010. View at: Publisher Site | Google Scholar
  28. G. D. Eslick and J. S. Kalantar, “Gastric metastasis in renal cell carcinoma: A case report and systematic review,” Journal of Gastrointestinal Cancer, vol. 42, no. 4, pp. 296–301, 2011. View at: Publisher Site | Google Scholar
  29. M.-Y. Kim, H.-Y. Jung, K. D. Choi et al., “Solitary synchronous metastatic gastric cancer arising from T1b renal cell carcinoma: A case report and systematic review,” Gut and Liver, vol. 6, no. 3, pp. 388–394, 2012. View at: Publisher Site | Google Scholar
  30. J. Xu, S. Latif, and S. Weia, “Metastatic renal cell carcinoma presenting as gastric polyps: A case report and review of the literature,” International Journal of Surgery Case Reports, vol. 3, no. 12, pp. 601–604, 2012. View at: Publisher Site | Google Scholar
  31. H. P. P. Siriwardana, M. H. Harvey, S. S. Kadirkamanathan, B. Tang, D. Kamel, and R. Radzioch, “Endoscopic mucosal resection of a solitary metastatic tumor in the stomach: A case report,” Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, vol. 22, no. 3, pp. e132–e134, 2012. View at: Publisher Site | Google Scholar
  32. T. Namikawa, J. Iwabu, H. Kitagawa, T. Okabayashi, M. Kobayashi, and K. Hanazaki, “Solitary gastric metastasis from a renal cell carcinoma, presenting 23 years after radical nephrectomy,” Endoscopy, vol. 44, no. 2, pp. E177–E178, 2012. View at: Publisher Site | Google Scholar
  33. S. Rodrigues, P. Bastos, and G. MacEdo, “A rare cause of hematemesis: Gastric metastases from renal cell carcinoma,” Gastrointestinal Endoscopy, vol. 75, no. 4, pp. 894-895, 2012. View at: Publisher Site | Google Scholar
  34. R. Chibbar, J. Bacani, and S. Zepeda-Gómez, “Endoscopic mucosal resection of a large gastric metastasis from renal cell carcinoma,” ACG Case Reports Journal, vol. 1, no. 1, pp. 10–12, 2013. View at: Google Scholar
  35. D. Greenwald, E. Aljahdli, D. Nepomnayshy et al., “Synchronous gastric metastasis of renal cell carcinoma with absence of gastrointestinal symptoms,” ACG Case Reports Journal, vol. 1, no. 4, pp. 196–198, 2014. View at: Google Scholar
  36. T. N. Costa, F. R. Takeda, U. Ribeiro, and I. Cecconello, “Palliative laparoscopic resection of renal cell carcinoma metastatic to the stomach: Report of a case,” World Journal of Surgical Oncology, vol. 12, no. 1, article no. 394, 2014. View at: Publisher Site | Google Scholar
  37. E. Kumcu, M. Gönültas, and H. Ünverdĭ, “Gastric metastasis of a renal cell carcinoma presenting as a polypoid mass,” Endoscopy, vol. 46, supplement 1, no. UCTN:E464, 2014. View at: Publisher Site | Google Scholar
  38. K. Sakurai, K. Muguruma, S. Yamazoe et al., “Gastric metastasis from renal cell carcinoma with gastrointestinal bleeding: a case report and review of the literature,” International Surgery, vol. 99, no. 1, pp. 86–90, 2014. View at: Publisher Site | Google Scholar
  39. J. Forman, J. Marshak, Y. A. Tseng et al., “Image of the month: gastric metastasis of renal clear cell carcinoma,” The American Journal of Gastroenterology, vol. 110, article 15, no. 1, 2015. View at: Google Scholar
  40. M. Kongnyuy, S. Lawindy, D. Martinez et al., “A rare case of the simultaneous, multifocal, metastatic renal cell carcinoma to the ipsilateral left testes, bladder, and stomach,” Case Reports in Urology, vol. 2016, Article ID 1829025, 3 pages, 2016. View at: Publisher Site | Google Scholar

Copyright © 2017 Mouhanna Abu Ghanimeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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