Case Reports in Gastrointestinal Medicine

Case Reports in Gastrointestinal Medicine / 2018 / Article

Case Report | Open Access

Volume 2018 |Article ID 3295204 | 4 pages | https://doi.org/10.1155/2018/3295204

Acute Gastrointestinal Bleeding in Olmesartan-Associated Collagenous Gastroduodenitis: A Potential Endoscopic Complication

Academic Editor: Chia-Tung Shun
Received03 Nov 2017
Accepted12 Feb 2018
Published14 Mar 2018

Abstract

Collagenous gastroenteritis is a rare disease that is known to be associated with the drug olmesartan, an angiotensin II receptor antagonist used to treat hypertension. It is characterized histologically by increased subepithelial collagen deposition with associated inflammation and epithelial injury. Endoscopically, the mucosa appears inflamed and friable and may be nodular or atrophic. We report a case of acute gastric bleeding on direct mucosal contact during endoscopy in a patient with olmesartan-associated collagenous gastroduodenitis to raise awareness of this potential endoscopic complication.

1. Introduction

Collagenous gastroenteritis is a pattern of injury that is characterized histologically by subepithelial collagen deposition >10 μm in thickness with associated mucosal inflammation and epithelial injury [1]. The collagen bands are usually irregular, often entrap small capillaries, and can be highlighted with a trichrome stain. It is a rare disorder that may involve the stomach (collagenous gastritis) and/or small bowel (collagenous enteritis/sprue) and may occasionally coexist with the more common entity, collagenous colitis. The etiology of collagenous gastroenteritis is unknown but is suspected to be immune-mediated and may be associated with certain medications including the antihypertensive drug olmesartan, an angiotensin II receptor antagonist [2]. Several reports in the literature describe cases of olmesartan-associated collagenous duodenitis/sprue [35] with fewer reports of olmesartan-associated collagenous gastritis [3, 6] and only rare reports involving both the stomach and small bowel [3]. We herein report a case of olmesartan-associated collagenous gastroduodenitis that was complicated by acute gastrointestinal bleeding during endoscopy.

2. Case Presentation

A 64-year-old woman presented to the gastroenterologist with abdominal pain, unintentional 10 pound weight loss over 3 months, and reflux symptoms. Pertinent medical history included hypertension treated with olmesartan 20 mg once a day for the past 7 years, hyperlipidemia treated with simvastatin, gastroesophageal reflux disease treated with pantoprazole 20 mg twice a day, and osteoporosis treated with denosumab injections every 6 months. Esophagogastroduodenoscopy (EGD) performed in the office showed granular mucosa in the proximal duodenum and nodular mucosa in the stomach with numerous linear ulcers. On withdrawal of the scope from the duodenum, a large amount of fresh blood was noted in the stomach with clotted blood near the cardia. The bleeding was believed to be due to either the underlying gastric ulcers or a Mallory Weiss tear. The patient was transferred to the emergency department for further evaluation.

On admission, the hemoglobin and hematocrit were normal, and an emergent EGD was performed. The gastric fundus and body appeared atrophic with friable and severely inflamed mucosa and multiple linear ulcers without active bleeding (Figure 1). The antral mucosa appeared erythematous. Biopsies of the stomach and duodenum were performed. The biopsies of the antrum and body showed increased subepithelial collagen deposition confirmed on a trichrome stain, chronic inflammation in the lamina propria, surface epithelial regenerative changes, and erosions, consistent with collagenous gastritis (Figure 2). The gastric body mucosa was atrophic with near-total loss of parietal cells. Immunostain for H. pylori organisms was negative, and a Congo red stain for amyloid was negative. The biopsies of the duodenum showed partial villous atrophy and increased subepithelial collagen deposition confirmed on a trichrome stain, consistent with collagenous duodenitis/sprue (Figure 3). The patient was started on high dose acid suppression with pantoprazole 40 mg twice a day, and the olmesartan was discontinued.

Follow-up EGD 7 weeks later showed somewhat atrophic gastric mucosa with few residual linear areas of erythema and complete resolution of the ulcers, inflammation, and mucosal friability (Figure 4). The duodenal mucosa appeared normal. Colonoscopy was unremarkable. Repeat biopsies showed marked improvement of the collagenous gastritis with resolution of the epithelial injury and only rare residual foci of subepithelial collagen. A mild nonspecific chronic inactive gastritis remained present. The biopsies from the duodenum and left colon showed normal mucosa without evidence of collagenous duodenitis or collagenous colitis.

3. Brief Discussion

Olmesartan-associated collagenous gastroenteritis is a rare entity that may be immune-mediated in nature. The length of time of olmesartan use before onset of symptoms varies from less than 1 month to 11 years [7]. When the stomach is solely involved, symptoms include dyspepsia, anemia due to bleeding, weight loss, and diarrhea. When the small intestine is involved, the most common symptoms are watery diarrhea and weight loss due to malabsorption [2]. The characteristic endoscopic finding of collagenous gastritis is nodular mucosa. Other findings include erythema, mucosal friability, erosions, ulcers, and atrophy [2, 6]. The endoscopic findings in the small bowel are nonspecific and include pale mucosa, mucosal thickening, and scalloping [2, 4].

The diagnostic histologic feature of collagenous gastroenteritis is band-like layer of subepithelial collagen deposition that is at least 10 μm in thickness and is associated with a chronic inflammatory infiltrate and surface epithelial injury [1]. The deposits can be patchy and irregular and often entrap superficial dilated capillaries [2]. Bleeding results from surface epithelial injury and sloughing which exposes these capillaries.

The majority of cases of olmesartan-associated collagenous gastroenteritis reported in the literature resolved after cessation of the drug [7]. One study reported complete clinical and pathologic resolution of collagenous duodenitis after treatment with the immunosuppressive drugs FK-506 and rapamycin [8]. Our patient had a complete clinical response and near-complete pathologic response at 7-week follow-up after discontinuation of olmesartan.

In summary, we report a case of acute gastric bleeding during endoscopy due to olmesartan-associated collagenous gastroduodenitis. The mechanism of bleeding in this disease is the presence of abnormal subepithelial collagen causing mucosal fragility. Bleeding may be spontaneous and chronic with associated anemia or may be acute and caused by direct contact with instruments during endoscopy, as was believed to be the reason for the acute bleed in this case. Although rare, it is important for endoscopists to be aware of this potential endoscopic complication in patients taking olmesartan.

Conflicts of Interest

There are no conflicts of interest or funding sources.

References

  1. R. B. Colletti and T. D. Trainer, “Collagenous gastritis,” Gastroenterology, vol. 97, no. 6, pp. 1552–1555, 1989. View at: Publisher Site | Google Scholar
  2. O. H. Nielsen, L. B. Riis, S. Danese, R. D. Bojesen, and C. Soendergaard, “Proximal collagenous gastroenteritides: clinical management: a systematic review,” Annals of Medicine, vol. 46, no. 5, pp. 311–317, 2014. View at: Publisher Site | Google Scholar
  3. A. Rubio-Tapia, M. L. Herman, J. F. Ludvigsson et al., “Severe spruelike enteropathy associated with olmesartan,” Mayo Clinic Proceedings, vol. 87, no. 8, pp. 732–738, 2012. View at: Publisher Site | Google Scholar
  4. J. A. Nielsen, A. Steephen, and M. Lewin, “Angiotensin-II inhibitor (olmesartan)-induced collagenous sprue with resolution following discontinuation of drug,” World Journal of Gastroenterology, vol. 19, no. 40, pp. 6928–6930, 2013. View at: Publisher Site | Google Scholar
  5. C. Desruisseaux, M. Bensoussan, E. Désilets et al., “Adding water to the mill: olmesartan-induced collagenous sprue—a case report and brief literature review,” Canadian Journal of Gastroenterology and Hepatology, vol. 2016, Article ID 4837270, 2 pages, 2016. View at: Publisher Site | Google Scholar
  6. C. Ma, J. Y. Park, E. A. Montgomery et al., “A comparative clinicopathologic study of collagenous gastritis in children and adults: The same disorder with associated immune-mediated diseases,” The American Journal of Surgical Pathology, vol. 39, no. 6, pp. 802–812, 2015. View at: Publisher Site | Google Scholar
  7. N. Burbure, B. Lebwohl, C. Arguelles-Grande, P. H. R. Green, G. Bhagat, and S. Lagana, “Olmesartan-associated sprue-like enteropathy: A systematic review with emphasis on histopathology,” Human Pathology, vol. 50, pp. 127–134, 2016. View at: Publisher Site | Google Scholar
  8. S. Scialom, G. Malamut, B. Meresse et al., “Gastrointestinal disorder associated with olmesartan mimics autoimmune enteropathy,” PLoS ONE, vol. 10, no. 6, article e0125024, 2015. View at: Publisher Site | Google Scholar

Copyright © 2018 Rachel Hudacko and Lance Siegel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

954 Views | 359 Downloads | 0 Citations
 PDF  Download Citation  Citation
 Download other formatsMore
 Order printed copiesOrder

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.