Salivary Gland Heterotopia in the Gastroesophageal Junction: A Case Series and Review of the Literature

Table 1

Location, clinical features, endoscopic findings, and histopathology of salivary gland heterotopias at the gastroesophageal junction.

	Age/Sex	Location	Clinical	Endoscopy	Histopathology
	44m	GE Junction	8 month history of gastro-esophageal reflux disease (GERD).	Polypoid shaped, hypoechoic mass measuring 1 cm in size and confined to the deep mucosa and submucosa	Prominent mucus glands with chronic inflammation consistent with heterotopic salivary glands surrounded by prominent adipose tissue and congested vessels in the submucosa (Figures 1 and 2).
	62 m	GE Junction	History of hypothyroidism, Sjogren’s syndrome, Raynaud syndrome, chronic GERD and grade 3 esophagitis	Dilated esophagus with an irregular z-line and 2 small islands of salmon colored mucosa immediately proximal to the GE junction	Focal mild acute erosive esophagitis and basal hyperplasia that was consistent with reflux and detached fragment of salivary gland type glandular tissue with chronic inflammation consistent with heterotopic salivary gland tissue (Figures 3 and 4)
	72 m	GE Junction	Past medical history of Barrett’s esophagus and high-grade dysplasia presented to rule out invasive carcinoma	Concerning focal area of ulceration which was removed via EMR	Focal high-grade dysplasia, cavernous and ectatic venous channels as well as a few prominent lobules of minor salivary glands with cystification (Figures 5 and 6)