Case Reports in Gastrointestinal Medicine

Case Reports in Gastrointestinal Medicine / 2021 / Article

Case Report | Open Access

Volume 2021 |Article ID 6699867 | https://doi.org/10.1155/2021/6699867

Nicholas Lazar, Kamil Sardarli, Zaid Imam, Majd Khasawneh, Ismail Hader, "A Rare Twist of the Forgotten Disease: A Case of Fusobacterium necrophorum Sepsis with Portomesenteric Thrombosis and a Review of the Literature", Case Reports in Gastrointestinal Medicine, vol. 2021, Article ID 6699867, 7 pages, 2021. https://doi.org/10.1155/2021/6699867

A Rare Twist of the Forgotten Disease: A Case of Fusobacterium necrophorum Sepsis with Portomesenteric Thrombosis and a Review of the Literature

Academic Editor: Chia-Tung Shun
Received07 Dec 2020
Accepted22 May 2021
Published28 May 2021

Abstract

Abdominal variants of Lemierre’s syndrome presenting with pylephlebitis are rare, and the role of anticoagulation in treatment is controversial. We hereby report a case of pylephlebitis secondary to F. necrophorum bacteremia in a 57-year-old female originating from bacterial translocation secondary to colitis, who developed a favorable outcome with prompt treatment with antibiotics and anticoagulation. We also perform a literature review on similar cases in the literature and discuss management options of this rare but potentially fatal complication.

1. Introduction

Lemierre’s syndrome, known as the “forgotten disease” is defined by septic thrombophlebitis of the internal jugular vein in the setting of Fusobacterium necrophorum infection. Pylephlebitis or septic thrombophlebitis of the portal venous system is a rare complication of appendicitis, cholecystitis, pancreatitis, diverticulitis, and other intra-abdominal infections [1]. It presents with fever, abdominal pain, nausea, and vomiting and carries a mortality ranging between 25–80%, and early recognition is key to improved outcomes [14]. Abdominal variants of Lemierre’s syndrome with pylephlebitis are exceedingly rare and present management controversies, particularly regarding anticoagulation [4,5]. Hereby, we report a case of pylephlebitis secondary to F. necrophorum bacteremia and review relevant literature on this complication.

2. Case Report

A 57-year-old female with prior history of nonischemic cardiomyopathy and alcohol abuse was admitted to our facility with a three-day history of myalgias and chills. Accompanied by her husband, he corroborated that she became increasingly confused over the same duration. She had no prior history of cirrhosis or chronic pancreatitis. A review of systems was otherwise negative. She had no recent dental work or procedures. On exam, she was ill-appearing with no abdominal tenderness or guarding, a normal cardiopulmonary examination, and negative meningeal signs. She was febrile to 39.1°C (102.4°F), tachycardiac to 113 beats/minute, had a blood pressure of 113/80 mmHg, and was saturating well on room air.

Initial labs revealed a neutrophil count of 9,100 cells/mm [3], platelet count of 91,000 cells/mm [3], and lactic acid of 1.0 (normal: <2) mmol/L. Mild elevations in her aspartate aminotransferase (AST) and alanine aminotransferase to 55 (normal: 10–37) U/L and 62 (normal: 8–37) U/L, respectively, were noted with a normal alkaline phosphatase level of 58 (normal: 30–110) U/L. A chest X-ray and urinalysis were normal, and blood cultures were obtained. The patient rapidly deteriorated, became hypotensive and was resuscitated with isotonic fluid boluses, started on broad spectrum antibiotics with intravenous vancomycin and meropenem given a prior history of allergy to penicillin, and admitted to the intensive-care unit.

On her second day of admission, her mentation improved but she developed profuse, watery diarrhea and lower abdominal pain. Clostridium difficile testing and stool cultures were obtained and were negative. A computed tomography of her abdomen and pelvis with intravenous and oral contrast showed mild sigmoid colitis but no definite evidence of diverticulitis and cholelithiasis with no pericholecystic fluid (Figure 1). On day 2 of admission, the blood cultures returned positive for a Gram-negative bacillus identified on day 4 as F. necrophorum. A progressive elevation of her liver chemistries to ALP of 415 U/L, AST of 154 U/L, ALT of 134 U/L, and total bilirubin of 1.5 mg/dl prompted evaluation with a magnetic resonance pancreaticography (MRCP) for a biliary source of infection. Her common bile duct was normal in diameter at 7 mm with no filling defects, no extra- or intrahepatic biliary duct dilatation, and no pericholecystic inflammation or evidence of pancreatitis noted. However, the MRCP identified nonocclusive thrombosis of the proximal superior mesenteric vein and a few right portal vein branches with adjacent impaired hepatic perfusion. Given these findings and concern for focal hepatic tissue infarction, anticoagulation with intravenous heparin was initiated for a total of 72 hours titrated to a goal activated partial thromboplastin time (aPTT) of 60–80 seconds before transitioning to apixaban 5 mg twice daily.

With continued supportive care and antibiotic therapy, the patient improved gradually, her symptoms resolved, and she was discharged from our facility to complete a 14-day course of ertapenem. Additionally, she was treated with apixaban 5 mg twice daily for 3 months for her portomesenteric thrombosis. Her treatment course was uneventful, and no bleeding events occurred.

To date, the reported patient had two subsequent episodes of sigmoid diverticulitis 1 year later, the latter of which was complicated by perforation requiring a lower anterior resection, ileostomy placement, and subsequent reversal. She recovered well from her operations and has had no recurrent portal, mesenteric, or venous thromboses.

3. Discussion

Fusobacterium necrophorum is a commensal Gram-negative bacillus colonizing the respiratory, gastrointestinal, and female genital tract [6] and implicated as the causative agent of Lemierre’s syndrome manifesting with septic internal jugular vein thrombophlebitis and often with septic pulmonary emboli [6, 7]. Pylephlebitis, or suppurative thrombophlebitis of the portomesenteric venous system, is a rare complication of intra-abdominal infections and is hardly ever a sequela of Fusobacterium spp. septicemia [4]. We hereby report a case of septic portomesenteric thrombosis secondary to Fusobacterium necrophorum bacteremia in the setting of sigmoid colitis to add to a total of 21 cases of Fusobacterium-spp.-infection-related pylephlebitis reported in the literature [827].

Clinically, pylephlebitis presents with fever, abdominal pain, hepatosplenomegaly, and, less commonly, ascites [4]. Neutrophilic leukocytosis and liver chemistry disturbances are commonly encountered in pylephlebitis from all bacterial etiologies [3, 4]. In reported cases of Fusobacterium-associated pylephlebitis (Table 1); liver enzyme abnormalities occurred in 16 (72.7%) patients, including the reported case. The median patient age in Fusobacterium-spp.-associated pylephlebitis was 52 years (interquartile range (IQR): 36–63) similar to a case series of patients with pylephlebitis from other bacterial etiologies and the age of the reported patient [5].


Author (year)Age, \sexComorbiditiesSymptomsBilirubin (mg/dl)ALP (U/L)AST (U/L)ALT (U/L)Source of infectionImaging modality

Presented case57, FEtOH abuse and nonischemic CMFever, myalgias, and confusion1.4348124104ColitisMRCP
Abdallah et al. (2020)37, MMigrainesEtOH abuse fever, diarrhea, and abdominal pain2.7174152167DiverticulitisCT
Hamera et al. (2019)51, MUC, T2DM, and COPDFever and weakness1.645112CholangitisUS and CT
Le Roux et al. (2006)43, MEtOH abuse and pancreatitisFever and myalgiasNLNLNLNLNo source identifiedUS and CT
Mellor et al. (2017)64, MNoneFever, diarrhea, and abdominal pain3.4234Diverticulitis and pericolonic abscessCT
Moore et al. (2016)60, MNot specifiedFever, epigastric pain, and weight lossNLNLNLNLUnclear sourceCT
Radovanovic et al. (2019)69, MHNSCCFever and abdominal pain300Liver abscessCT and MRI
Rahmati et al. (2017)59, FMultiple sclerosisAbdominal pain, fatigue, and weight loss1.62644741Hepatic abscessCT and MRI
Tharu and et al (2020)41, MDiverticulosisFever and diarrhea152Hepatic and brain abscessesCT
Akhrass et al. (2015)32, MNoneEpigastric painNLNLNLNLAcute perforated appendicitisUS and CT
Zheng et al. (2014)73, MHypertension, T2DM, and CADFever and epigastric painNLNLNLNLNo identified sourceCT
Hamidi et al. (2008) case 123, MNoneFever, epigastric pain, diarrhea, and jaundice9.4528No identified sourceYS
Hamidi et al. (2008) case 241, MEtOH abuseFever, abdominal pain, and jaundice5.325459No identified sourceCT
Soo et al. (1999)31, MNoneFever, abdominal pain, diarrhea, and jaundice5.929579133No identified sourceUS and MRI
Shahani et al. (2011)34, MEtOH abuse and chronic pancreatitisEpigastric painNLNLNLNLHepatic, pancreatic, and splenic abscessesCT
Clarke et al. (2003)19, FPreviously healthyFever, abdominal pain, and jaundice5.733152Hepatic abscessesUS and CT
Redford et al. (2005)53, MPreviously healthyFever, abdominal pain, and vomiting1.4194No identified sourceCT
Bultink et al. (1999)23, MPreviously healthy and oropharyngeal infection 5 weeks priorFever, abdominal pain, and vomiting192113Possible pharyngitisUS and CT
Verna et al. (2004)56, MUCFever, anorexia, and jaundice4.9305123No identified sourceCT
El Braks et al. (2004)71, FUrinary incontinenceFever, sore throat, and epigastric pain1.652173PharyngitisUS and CT
Etienne et al. (2001)68, MTB and pulmonary embolism (not on anticoagulation)FeverPossible oropharyngeal source and concomitant liver abscessCT
Schweigart et al. (2005)67, MTB, stroke, T2DM, and upper respiratory infection weeks priorFatigue, night sweats, and nausea175Possible oropharyngeal sourceCT and MRI

Abbreviations: M: male, F: female, TB: tuberculosis, T2DM: type 2 diabetes mellitus, UC: ulcerative colitis, HNSCC: head and neck squamous cell cancer, COPD: chronic obstructive pulmonary disease, CAD: coronary artery disease, EtOH: alcohol, CM: cardiomyopathy, ALP: alkaline phosphatase, AST: asparatate aminotransferase, ALT: alanine aminotransferase, CT: computed tomography, US: ultrasound, MRI: magnetic resonance imaging, MRCP: magnetic resonance pancreaticography, NL: reported normal.

In Fusobacterium-spp.-associated pylephlebitis, hepatic abscesses (27%) and oropharyngeal infections (13.6%) represented the most common identified primary infection site, and no clear primary infection site was identified in 36.4% of patients (Table 1). This contrasts with pylephlebitis from other bacterial etiologies whereby diverticulitis, pancreaticobiliary etiologies, and intra-abdominal abscesses represent the most common identified primary infection sites [4, 5]. In the reported case, bacteremia from sigmoid colitis represents the likely source of infection in the absence of an alternative site and the patient’s diarrhea.

Recent or remote abdominal surgery and immunosuppression have been reported as associated conditions with the development of pylephlebitis; however, pylephlebitis can occur in previously healthy individuals as well, highlighting the importance of a high index of suspicion in patients with intra-abdominal pathologies or Fusobacterium spp. bacteremia [3, 9, 12, 13, 15, 16, 22]. Diagnosis of pylephlebitis is based on confirmatory imaging findings of portal vein or mesenteric vein thrombosis in the setting of systemic infection. Intravenous contrast-enhanced computerized tomography (CT), ultrasonography, or magnetic resonance imaging (MRI) can all be used to establish the diagnosis, with the former reported as the modality of choice given its availability and high sensitivity [28].

Pylephlebitis complications include thrombus extension into the superior mesenteric vein (SMV), thrombosis of the intrahepatic branches of the portal vein, liver abscesses, and inferior mesenteric vein thrombosis, in descending order of frequency [3]. Intestinal ischemia, a feared complication, can occur in 25% of patients with SMV thrombosis, carrying a mortality of 20% [3, 29]. Fortunately, the presence of a nonocclusive SMV thrombus in the reported case rendered the patient not at risk for intestinal ischemia; however, early recognition and treatment was critical to prevent progression. Long-term complications of untreated pylephlebitis include risks of chronic thrombus formation and resulting portal hypertension with associated complications of variceal bleeding and portal cholangiopathy [30].

Of the twenty-two cases of fusobacterium-related pylephlebitis, 41% involved solely the PV, 32% involved some combination of the PV, SMV, IMV, or splenic vein, and 14% involved the SMV alone. There was isolated involvement of the right hepatic vein in two cases, and in only one case was the IMV solely affected (Table 2). The variability in thrombosis extent, variable anticoagulation, and follow-up periods render assessing whether thrombus extent affects long-term outcomes limited.


Author (year)Clot extentAntibiotic regimenAnticoagulation agentAnticoagulation durationOutcomes

Presented casePV and SMVI: vancomycin and meropenem
F: ertapenem (2 weeks)
UFH and apixaban3 monthsRecovery and elective sigmoidectomy 2 years later
Abdallah et al. (2020)PV, SMV, and IMVI: meropenem
F: ertapenem (1 month)
UFH and warfarin6 monthsRecovery and asymptomatic at 6-month follow-up
Hamera et al. (2019)PVI: meropenem
F: ceftriaxone/metronidazole (1 month)
Enoxaparin1 monthRecovery and no long-term follow-up
Le Roux et al. (2006)SMVF: amoxicillin-clavulanate and metronidazole (10 months)UFHHospitalizationRecovery, 10-month follow-up, and abdominal US with chronic PVT
Mellor et al. (2017)IMVI: piperacillin-tazobactam
F: ertapenem (1 month)
UFHHospitalizationRecovery, 1-month follow-up, and CT with PVT resolution
Moore et al. (2016)Right PVI: piperacillin-tazobactam
F: metronidazole (4 weeks)
Enoxaparin and warfarin6 monthsRecovery and asymptomatic at follow-up
Radovanovic et al. (2019)PVI: ceftriaxone/metronidazole
F: amoxicillin-clavulanate (2 weeks)
Enoxaparin and warfarin3 monthsRecovery and asymptomatic at 1-month follow-up
Rahmati et al. (2017)PVI: ertapenem
F: ceftriaxone/metronidazole (2 months), ampicillin-clavulanate (2 months)
EnoxaparinRecovery and 4-month follow-up CT with cavernous PV transformation
Tharu and et al. (2020)Superior right hepatic veinI: vancomycin/ceftriaxone/metronidazole
F: ceftriaxone/metronidazole (6 weeks)
NoneRecovery and 1-month CT with PVT resolution
Akhrass et al. (2015)Main PV at the confluenceI: piperacillin-tazobactam
F: Clindamycin (6 weeks)
UFH and warfarin6 weeksRecovery and follow-up not reported
Zheng et al. (2014)Right hepatic veinI: cefepime
F: clindamycin
Enoxaparin and warfarinRecovery and 2-month follow-up
Hamidi et al. (2008) case 1SMVI: amoxicillin-clavulanate (during admission)
F: —
LMWH and fluindione6 monthsRecovery and 5-month follow-up US with PVT resolution
Hamidi et al. (2008) case 2SMVNoneNoneNoneLeft against medical advice
Soo et al. (1999)PV andSMVI: ciprofloxacin/metronidazole/penicillin
F: amoxicillin-clavulanate/metronidazole (6 weeks)
UFH and warfarin6 monthsRecovery and 4-month MRI with resolved PVT
Shahani et al. (2011)Left and right PV, SMV, and splenic veinI: vancomycin/meropenem
F: tigecycline (4 weeks)
NoneNoneRecovery and 2-month CT with cavernous PV transformation
Clarke et al. (2003)PV and SMVF: benzylpenicillin/metronidazole/ciprofloxacin (6 weeks)UFH and warfarinIndefiniteRecovery and 7-weeks US with PVT improvement
Redford et al. (2005)PVI: metronidazole/benzylpenicillin
F: clindamycin (5 weeks)
LMWH and warfarin3 monthsRecovery and 3-months follow-up
Bultink et al. (1999)PVI: imipenem
F: penicillin G (6 weeks)
IV heparinHospitalizationRecovery and 2-month US with chronic PVT
Verna et al. (2004)Left PVF: clindamycin (2 weeks)NoneNoneRecovery and 6-month CT with chronic PVT and left hepatic atrophy
El Braks et al. (2004)PV and SMVF: piperacillin-tazobactam (2 weeks) and ofloxacin (3 weeks)UFH and fluindione9 monthsRecovery and CT at follow-up (not reported) with chronic PVT
Etienne et al. (2001)PVF: cefotaxime and metronidazole (2 weeks) and metronidazole (2 weeks)LMWH3 weeksRecovery and 5-week US with resolution
Schweigart et al. (2005)PVF: clindamycinWarfarinIndefinitelyRecovery and no long-term follow-up

Abbreviations: I: initial regimen, F: final regimen, PV: portal vein, SMV: superior mesenteric vein, IMV: inferior mesenteric vein, CT: computed tomography, US: ultrasound, MRI: magnetic resonance imaging, UFH: unfractionated heparin, LMWH: low-molecular-weight heparin, PVT: portal vein thrombosis.

The mainstay treatment of pylephlebitis is fluid resuscitation, antibiotics, and often anticoagulation [4]. Antibiotic choices can be guided by culture and sensitivity when available or empirically with broad-spectrum enteric and anaerobic coverage [20, 21]. Two large case series report similar mortality in patients treated with a combination of anticoagulation and antibiotics vs. antibiotics only [4, 5]. However, anticoagulation lowers the risks of future chronic portal hypertension and, hence, is frequently utilized in the absence of contraindications [5]. The length of anticoagulation utilized is a minimum of 3 months, but the optimal duration is unclear [5]. Choices of anticoagulation include unfractionated heparin in the acute setting later transitioned to low molecular weight heparin, warfarin, or direct oral anticoagulants (DOAC) [5, 31]. Treatment of Fusobacterium-spp.-associated pylephlebitis in the same vein follows the same principles. However, significant heterogeneity has been reported in use and duration of anticoagulation, where some authors anticoagulated patients only for the duration of their hospitalization while others anticoagulated patients between 3–9 months (Table 2). Given the absence of other risk factors for recurrent thrombosis in our patient, we elected to treat the event like a provoked deep vein thrombosis for a duration of 3 months.

Interestingly, while mortality has been reported as 11% in one case series of patients with pylephlebitis [4] and 12% in another [5], short-term outcome of patients with Fusobacterium-spp.-associated pylephlebitis appears more favorable with illness resolution in all cases where follow-up was reported (21 of 22 cases) and no cases of mortality including the reported case (Table 2). While this may represent a less fulminant course, it could be secondary to selection reporting biases that case reports are inherently prone to.

In conclusion, we present a case of pylephlebitis, a rare and often deadly complication, in the context of Fusobacterium necrophorum bacteremia. Our patient, whose presentation was mild and nonspecific, later developed septic shock. Adequate supportive therapy, prompt antibiotic therapy, and anticoagulation therapy with a DOAC for 3 months resulted in a favorable outcome. We hope that the presented case and review of existing cases contribute to the understanding of the subtle and insidious course of this rare complication.

Data Availability

Data regarding this case/manuscript are available upon request from the corresponding author.

Informed consent was obtained from the patient for publication purposes.

Disclosure

The abstract of this paper was presented as a poster in the American College of Gastroenterology Meeting, Philadelphia, Pennsylvania, USA, 2018.

Conflicts of Interest

The authors report no conflicts of interest.

Authors’ Contributions

N.L is the primary author, wrote the first draft of the manuscript, and performed the literature review with K.S who also participated in writing the first draft of the manuscript. Z.I, M.K, and I.H supervised the entire work and participated in manuscript drafting and editing.

References

  1. J. W. Dean, S. O. Trerotola, V. J. Harris, J. J. Snidow, and D. Hawes, “Percutaneous management of suppurative pylephlebitis,” Journal of Vascular and Interventional Radiology, vol. 6, no. 4, pp. 585–588, 1995. View at: Publisher Site | Google Scholar
  2. E. J. Balthazar and P. Gollapudi, “Septic thrombophlebitis of the mesenteric and portal veins: CT imaging,” Journal of Computer Assisted Tomography, vol. 24, no. 5, pp. 755–760, 2000. View at: Publisher Site | Google Scholar
  3. T. Kanellopoulou, A. Alexopoulou, G. Theodossiades, J. Koskinas, and A. J. Archimandritis, “Pylephlebitis: an overview of non-cirrhotic cases and factors related to outcome,” Scandinavian Journal of Infectious Diseases, vol. 42, no. 11-12, pp. 804–811, 2010. View at: Publisher Site | Google Scholar
  4. A. J. Choudhry, Y. M. K. Baghdadi, M. A. Amr, M. J. Alzghari, D. H. Jenkins, and M. D. Zielinski, “Pylephlebitis: a review of 95 cases,” Journal of Gastrointestinal Surgery, vol. 20, no. 3, pp. 656–661, 2016. View at: Publisher Site | Google Scholar
  5. L. Naymagon, D. Tremblay, T. Schiano, and J. Mascarenhas, “The role of anticoagulation in pylephlebitis: a retrospective examination of characteristics and outcomes,” Journal of Thrombosis and Thrombolysis, vol. 49, no. 2, pp. 325–331, 2020. View at: Publisher Site | Google Scholar
  6. D. Creemers-Schild, F. Gronthoud, L. Spanjaard, L. G. Visser, C. N. M. Brouwer, and E. J. Kuijper, “Fusobacterium necrophorum, an emerging pathogen of otogenic and paranasal infections?” New Microbes and New Infections, vol. 2, no. 3, pp. 52–57, 2014. View at: Publisher Site | Google Scholar
  7. T. Riordan, “Human infection with fusobacterium necrophorum (necrobacillosis), with a focus on Lemierre’s syndrome,” Clinical Microbiology Reviews, vol. 20, no. 4, pp. 622–659, 2007. View at: Publisher Site | Google Scholar
  8. L. Zheng and B. Giri, “Gastrointestinal variant of Lemierre syndrome,” American Journal of Therapeutics, vol. 23, no. 3, pp. e933–e936, 2016. View at: Publisher Site | Google Scholar
  9. R. Soo, I. Gosbell, J. Gallo, and C. S. Pokorny, “Septic portal vein thrombosis due to Fusobacterium necrophorum,” Australian and New Zealand Journal of Medicine, vol. 29, no. 4, pp. 569-570, 1999. View at: Publisher Site | Google Scholar
  10. L. Shahani and N. Khardori, “Fusobacterium necrophorum-beyond Lemierres syndrome,” Case Reports, vol. 2011, p. bcr0720114527, 2011. View at: Publisher Site | Google Scholar
  11. J. H. Schweigart, A. Klotsas, S. Schelenz, and K. Dhatariya, “Portal vein thrombosis despite anticoagulation in a person with diabetes,” Journal of the Royal Society of Medicine, vol. 98, no. 4, pp. 161–163, 2005. View at: Publisher Site | Google Scholar
  12. M. R. Redford, R. Ellis, and C. J. Rees, “Fusobacterium necrophorum infection associated with portal vein thrombosis,” Journal of Medical Microbiology, vol. 54, no. 10, pp. 993–995, 2005. View at: Publisher Site | Google Scholar
  13. K. Hamidi, A. Pauwels, M. Bingen et al., “Thrombose veineuse mésentérico-porte aiguë associée à une septicémie à Fusobacterium necrophorum,” Gastroentérologie Clinique et Biologique, vol. 32, no. 8-9, pp. 734–739, 2008. View at: Publisher Site | Google Scholar
  14. R. El Braks, F. Harnois, N. Boutros et al., “Mesenteric adenitis and portal vein thrombosis due to Fusobacterium nucleatum,” European Journal of Gastroenterology & Hepatology, vol. 16, no. 10, pp. 1063–1066, 2004. View at: Publisher Site | Google Scholar
  15. M. G. Clarke, N. J. Kennedy, and K. Kennedy, “Serious consequences of a sore throat,” Annals of the Royal College of Surgeons of England, vol. 85, no. 4, pp. 242–244, 2003. View at: Publisher Site | Google Scholar
  16. F. A. Akhrass, L. Abdallah, S. Berger, and R. Sartawi, “Gastrointestinal variant of Lemierre’s syndrome complicating ruptured appendicitis,” IDCases, vol. 2, no. 3, pp. 72–76, 2015. View at: Publisher Site | Google Scholar
  17. B. Nigussie, D. Woredekal, F. I. Abaleka, M. Gizaw, and B. Tharu, “A sporadic case of disseminated fusobacterium causing pylephlebitis and intracranial and hepatic abscesses in a healthy young patient,” Cureus, vol. 12, no. 7, 2020. View at: Publisher Site | Google Scholar
  18. J. A. Moore and S. Rambally, “Fusobacterium nucleatum bacteremia presenting with portal vein thrombosis: an abdominal Lemierre syndrome?” The American Journal of Medicine, vol. 130, no. 6, pp. e255–e256, 2017. View at: Publisher Site | Google Scholar
  19. K. Le Roux, P. Sève, E. Gomard et al., “Un variant du syndrome de Lemierre: abcès hépatiques et thrombose veineuse sus-hépatique secondaire à une septicémie à Fusobacterium nucleatum,” La Revue de Médecine Interne, vol. 27, no. 6, pp. 482–486, 2006. View at: Publisher Site | Google Scholar
  20. M. Abdallah, A. Gohar, S. Naryana Gowda, H. M. Abdullah, and A. Al-hajjaj, “Pylephlebitis associated with inferior mesenteric vein thrombosis treated successfully with anticoagulation and antibiotics in a 37-year-old male,” Case Reports in Gastrointestinal Medicine, vol. 2020, 3 pages, 2020. View at: Publisher Site | Google Scholar
  21. S. Pérez-Bru, C. Nofuentes-Riera, A. García-Marín, P. Luri-Prieto, M. Morales-Calderón, and S. García-García, “Pileflebitis: una extraña pero posible complicación de las infecciones intraabdominales,” Cirugía Y Cirujanos, vol. 83, no. 6, pp. 501–505, 2015. View at: Publisher Site | Google Scholar
  22. T. E. Mellor, N. Mitchell, and J. Logan, “Lemierre’s syndrome variant of the gut,” BMJ Case Reports, vol. 2017, 2017. View at: Publisher Site | Google Scholar
  23. M. Etienne, I. Gueit, P. Abboud, J.-L. Pons, S. Jacquot, and F. Caron, “Fusobacterium nucleatum hepatic abscess with pylephlebitis associated with idiopathic CD4+ T lymphocytopenia,” Clinical Infectious Diseases, vol. 32, no. 2, pp. 326–328, 2001. View at: Publisher Site | Google Scholar
  24. E. C. Verna, A. Larghi, S. G. Faddoul, J. A. Stein, and H. J. Worman, “Portal vein thrombosis associated with fusobacterium nucleatum septicemia in a patient with ulcerative colitis,” Journal of Clinical Gastroenterology, vol. 38, no. 7, pp. 611-612, 2004. View at: Publisher Site | Google Scholar
  25. I. E. M. Bultink, J. W. Dorigo-Zetsma, M. G. Koopman, and E. J. Kuijper, “Fusobacterium nucleatumSepticemia and portal vein thrombosis,” Clinical Infectious Diseases, vol. 28, no. 6, pp. 1325-1326, 1999. View at: Publisher Site | Google Scholar
  26. N. Radovanovic, I. Dumic, M. Veselinovic et al., “Fusobacterium necrophorum subsp. necrophorum liver abscess with pylephlebitis: an abdominal variant of Lemierre’s syndrome,” Case Reports in Infectious Diseases, vol. 2020, 6 pages, 2020. View at: Publisher Site | Google Scholar
  27. E. Rahmati, R. C. She, B. Kazmierski, P. J. Geiseler, and D. Wong, “A case of liver abscess and fusobacterium septicemia,” IDCases, vol. 9, pp. 98–100, 2017. View at: Publisher Site | Google Scholar
  28. W.-K. Lee, S. D. Chang, V. A. Duddalwar et al., “Imaging assessment of congenital and acquired abnormalities of the portal venous system,” Radiographics, vol. 31, no. 4, pp. 905–926, 2011. View at: Publisher Site | Google Scholar
  29. S. Acosta, A. Alhadad, P. Svensson, and O. Ekberg, “Epidemiology, risk and prognostic factors in mesenteric venous thrombosis,” British Journal of Surgery, vol. 95, no. 10, pp. 1245–1251, 2008. View at: Publisher Site | Google Scholar
  30. J. Hoekstra and H. L. A. Janssen, “Vascular liver disorders (II): portal vein thrombosis,” Netherlands Journal of Medicine, vol. 67, no. 2, 2009. View at: Google Scholar
  31. P. Priyanka, J. T. Kupec, M. Krafft, N. A. Shah, and G. J. Reynolds, “Newer oral anticoagulants in the treatment of acute portal vein thrombosis in patients with and without cirrhosis,” International Journal of Hepatology, vol. 2018, 9 pages, 2018. View at: Publisher Site | Google Scholar

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