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Case Reports in Hematology
Volume 2011, Article ID 818469, 3 pages
Case Report

Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature

1Department of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, Denmark
2Department of Pathology, Aalborg Hospital, Aarhus University Hospital, 9100 Aalborg, Denmark

Received 24 July 2011; Accepted 15 September 2011

Academic Editors: L.-M. Benjamin, D. Galanakis, K. Khair, and R. Lowenthal

Copyright © 2011 Anders Kindberg Boysen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.