Erdheim-Chester Disease Associated with Marginal Zone Lymphoma and Monoclonal Proteinemia
Figure 1
Morphologic features of lymph node. Images are from the antemortem lymph node biopsy. (a and b) CD20 and CD68 immunoperoxidase stains highlight the B-cell-rich and histiocyte-rich regions, the lymph node corresponding to areas involved by marginal zone B-cell lymphoma (a) and Erdheim-Chester disease (b), respectively, 100x magnification. (c and e) lymphoplasmacytic infiltrate present in the B-cell-rich areas, hematoxylin, and eosin, 200x and 400x magnification. (d and f) Histiocytic infiltrate with occasional Touton type giant cells in histiocyte-rich-regions, 200x and 1000x magnification. (g and h) In situ hybridization for kappa (g), and lambda (h), in lymphoplasmacytic areas of lymph node demonstrating lambda predominance, 100x magnification.
