Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2012, Article ID 180204, 3 pages
http://dx.doi.org/10.1155/2012/180204
Case Report

Anaplastic Large Cell Lymphoma Occurring in an HIV-Positive Patient

Service d’Hématologie, Centre Hospitalier Victor Dupouy, 69 Rue du Lieutenant-Colonel Prudhon, 95100 Argenteuil, France

Received 30 October 2012; Accepted 29 November 2012

Academic Editors: G. Feher, K. Kawauchi, and K. Nakase

Copyright © 2012 Philippe Genet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cases of anaplastic large-cell lymphoma (ALCL) of T phenotype are sparse in the setting of HIV patients. We report herein a case of T-ALCL, with an advanced stage, pulmonary involvement, high HIV viral load, and low CD4 level. Anaplastic lymphoma kinase (ALK) protein expression was negative. Anthracyclin-based chemotherapy was unsuccessful. The literature review was performed focusing on incidence, clinical characteristics, prognosis, and physiopathology of ALCL in HIV patients. More data are needed to improve the knowledge of such cases and to define a better treatment approach.