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Case Reports in Hematology
Volume 2012, Article ID 194312, 5 pages
http://dx.doi.org/10.1155/2012/194312
Case Report

Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8

1Department of Internal Medicine, Vidant Medical Center Greenville, NC 27835, USA
2Division of Pulmonary and Critical Care Medicine, East Carolina University and Vidant Medical Center, Greenville, NC 27835, USA
3Departments of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine, East Carolina University and Vidant Medical Center, Greenville, NC 27835, USA

Received 13 April 2012; Accepted 22 June 2012

Academic Editors: C. Imai, Y. Shiozawa, and P. Tsirigotis

Copyright © 2012 Muhammad Rizwan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors and may involve multiple sites of the body, but involvement of male breast is extremely rare. In the absence of clinical history or hematological abnormality, GS may be misdiagnosed, depending on the degree of myeloid differentiation present within the tumor. Often it is misdiagnosed as lymphoma. Diagnosis is made by finding eosinophilic myelocytes, myeloperoxidase, chloroacetate esterase staining, and lysozyme immunostain. Chemotherapy regimens similar to acute myeloid leukemia are recommended to treat GS. Recognition of this rare entity is important because early, aggressive chemotherapy can induce regression of the tumor and improve patient longevity.