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Case Reports in Hematology
Volume 2012, Article ID 530908, 3 pages
Case Report

Successful Management of Acute Catastrophic Juvenile Vaginal Bleeding in Glanzmann’s Thromboasthenia by Uterine Tamponade: A Case Report and Review of The Literature

1Department of Obstetrics & Gynecology Unit 3, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi 74200, Pakistan
2National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan
3Dow University of Health Sciences, Baba-e-Urdu Road, Karachi 74200, Pakistan

Received 27 December 2011; Accepted 16 January 2012

Academic Editors: E. Arellano-Rodrigo and G. Feher

Copyright © 2012 Nazli Hossain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Glanzmann’s thromboasthenia (GT) is a rare platelet disorder, due to membrane defects involving glycoprotein GP IIb/IIIa complex. Symptoms appear in infancy with episodes of bruising, gingival bleeding, epistaxis, or at the time of menarche acute episode of uterine bleeding. Hormonal therapy and antifibrinolytic agents are first-line treatment. Platelet transfusion is given to control hemorrhage when medical treatment fails. However, repeated transfusions may result in development of platelet refractioness, due to development of antibodies against membrane glycoprotein. Activated recombinant FVII is licensed for use in acute control of bleeding in GT. Here we report a case of acute juvenile uterine bleeding at menarche, which responded successfully to uterine tamponade. To our knowledge, this is the first case report on use of balloon tamponade for control of acute catastrophic juvenile bleeding at menarche.