Case Reports in Hematology / 2012 / Article / Tab 1 / Case Report
Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma: A Case Report and Review of the Literature Table 1 Sequential analysis of peripheral blood and bone marrow changes.
Diagnosis Prefibrotic stage of primary myelofibrosis
JAK 2-positive primary myelofibrosis (IPSS score 1; DIPSS score 1 [1 , 2 ]) JAK 2-positive primary myelofibrosis and atypical B-lymphoid aggregates (IPSS score 3, DIPSS score 4) Acute myeloid leukemia and CD5-negative mantle cell lymphoma Time elapsed Onset 2 years 7 years 7 years and 9 months Peripheral Blood WBC (×109 /L) 16.7 16.4 59.3 40.3 Hgb (g/dL) 13.8 10.1 12.6 11 Platelets (×109 /L) 1346 575 303 202 Blasts (%) 0 0 5% 69% Bone Marrow Cellularity 50% 95% 95% 95% Reticulin 2+/4 4+/4 4+/4 4+/4 Blasts (%) <5% <5% 9% 73.4% Description Megakaryocytic hyperplasia, dysmegakaryopoiesis Dysmegakaryopoiesis Dysmegakaryopoiesis Blasts, dysmegakaryopoiesis Lymphoid aggregates None Single small aggregate Cyclin D1 negative IgH negative CD20+, CD5 negative, BCL2+, A few cells are Cyclin D1+ IgH positive Lymphoid aggregates 10%, CD5 negative, CD20+, BCL2+ Cyclin D1+ IgH positive FISH positive for t(11;14)
