A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy

Table 1

Platelet aggregation and activation assays.

	12/08	3/09	Normal
Platelet aggregation
ADP
Percentage of aggregation	78	61	70–100% max
ATP release	0.85	0.23	0.2–1.6 nM
AA
Percentage of aggregation	76	71	66–100% max
ATP release	0.68	0.29	0–1.3 nM
Collagen
Percentage of aggregation	87	74	70–100% max
ATP release	1.02	0.53	0.4–1.9 nM
Epinephrine
Percentage of aggregation	80	66	67–95% max
ATP release	1.02	0.54	0.3–1.7 nM
Platelet activation
Percentage of mepacrine uptake	33	63	54–84%
Percentage of mepacrine release	82	79	58–93%

ADP: adenosine diphosphate; AA: arachidonic acid.