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Case Reports in Hematology
Volume 2013 (2013), Article ID 231713, 4 pages
Case Report

Cyclic Bicytopenia in a Patient with Shapiro Syndrome

1Mayo Medical School, Mayo Clinic, Rochester, USA
2Department of Hematology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA

Received 17 July 2013; Accepted 29 August 2013

Academic Editors: U. Dasgupta, K. Kawauchi, P. Tsirigotis, and S. D. Wagner

Copyright © 2013 Lindsey E. Roeker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Shapiro syndrome and periodic hypothermia have been reported approximately fifty times in the literature. Shapiro syndrome is defined as the constellation of periodic hypothermia and hyperhidrosis along with agenesis of the corpus callosum by Shapiro et al. in 1969. Periodic hypothermia is a more broad diagnosis with a number of proposed mechanisms; it occurs in patients without structural brain abnormalities. Hematologic abnormalities beyond iron-deficiency anemia have not been documented in any of the reported cases of Shapiro syndrome or periodic hypothermia. Though accidental and therapeutic hypothermia have been associated with thrombocytopenia, this is, to our knowledge, the first reported case of periodic intrinsic hypothermia causing bicytopenia. In this report, we present the case of a patient with Shapiro syndrome who experienced cyclic bicytopenia mirroring hypothermic episodes. We address the differential diagnosis of bicytopenia, review the mechanisms proposed for cytopenias related to hypothermia, and propose possible mechanisms for the finding in this case.