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Case Reports in Hematology
Volume 2013, Article ID 269268, 4 pages
Case Report

Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura

1Fairview Hospital, Cleveland Clinic Health System, Cleveland, OH 44111, USA
2Case Western University School of Medicine, Cleveland, OH 44111, USA
3Hematology-Oncology, Fairview Hospital, Cleveland Clinic Health System, Cleveland, OH 44111, USA

Received 25 April 2013; Accepted 27 May 2013

Academic Editors: E. Bissé, R. Herrmann, M.-C. Kyrtsonis, and A. Ohsaka

Copyright © 2013 Ruchi Sood et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The most common cause of a neck mass in young adults is hyperplastic lymphadenopathy consequent to infection and inflammation. Castleman’s disease (CD), an unusual benign lymphoproliferative disorder, infrequently causes neck masses. It occurs in unicentric (UCD) and multicentric (MCD) forms and is associated with human immunodeficiency virus (HIV), human herpes virus 8 (HHV-8), and Kaposi's sarcoma. We present the third known association between MCD and previous immune thrombocytopenia in the absence of HIV and HHV-8 infection and review its association with other autoimmune disorders and attendant implications for pathogenesis. Finally, we summarize the current approach to therapy.