Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura

Figure 1

Marked angiofollicular hyperplasia representing hyaline vascular variant. Concentric “onion skin pattern” of peripheral lymphocytes (black arrow heads) surrounding a pale centered follicle (thin black arrow). Vascular proliferation (white arrow heads) is seen with capillaries demonstrating thickened walls and prominent endothelial cells. Penetrating hyalinized small vessel gives follicle a lollipop-like appearance (thin white arrow).