Case Reports in Hematology
Volume 2013, Article ID 563291, 4 pages
http://dx.doi.org/10.1155/2013/563291
t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
1Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 37232, USA
2Division of Pediatric Hematology/Oncology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 37232, USA
Received 19 November 2012; Accepted 12 December 2012
Academic Editors: D. J. Allsup, E. Arellano-Rodrigo, S. Langabeer, and P. Tsirigotis
Copyright © 2013 Katherine A. Minson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This translocation has been associated with hypercalcemia, coagulopathy, and poor outcome. We present three cases of ALL with t(17;19) treated at our institution and review the outcome of children reported in the medical literature.