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Case Reports in Hematology
Volume 2013 (2013), Article ID 840253, 6 pages
http://dx.doi.org/10.1155/2013/840253
Case Report

Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern

1Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UK
2Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UK

Received 6 August 2013; Accepted 11 September 2013

Academic Editors: C. Imai and K. Kawauchi

Copyright © 2013 Rowan L. Grigoropoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Anaplastic large cell lymphoma with a small cell pattern is a rare T-cell lymphoma. This condition is more frequently seen in younger patients and should be considered when patients present with leucocytosis and constitutional symptoms. In this report, we describe our diagnostic work-up for one such case using blood, lymph node, and bone marrow aspirate samples, highlighting the variability of antigen expression seen in different sample types and methodologies. This case shows the importance of having a high index of suspicion and assessing CD30 and anaplastic lymphoma kinase expression in all suspected T-cell neoplasms even though this rare condition is not necessarily expected.