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Case Reports in Hematology
Volume 2013, Article ID 931519, 3 pages
Case Report

Bendamustine Associated with Irreversible Ascending Paralysis

1Internal Medicine Department, University of Kansas Medical Center, Kansas City, KS 66160, USA
2Blood and Marrow Transplant Program, University of Kansas Medical Center, 2330 Shawnee Mission Pkwy, Westwood, Kansas City, KS 66205, USA

Received 22 January 2013; Accepted 3 February 2013

Academic Editors: U. Dasgupta, C. Imai, F. Kutlar, Y. Matsukawa, and K. Nakase

Copyright © 2013 Ashraf Alhafez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bendamustine is an alkylating agent currently used in the treatment of lymphoproliferative disorders. Many adverse effects, including a rare case of reversible neurotoxicity, have been reported in association with bendamustine. Herein, we report the first case of irreversible ascending paralysis related to bendamustine.