TY - JOUR A2 - Tsirigotis, Panagiotis AU - Khoulani, Dania AU - Rao, Bharat AU - Khanshour, Ammar AU - Kuriakose, Philip AU - Yessayan, Lenar PY - 2014 DA - 2014/07/10 TI - Failure of Recombinant Activated Factor VII in Treatment of Diffuse Alveolar Hemorrhage due to Cryoglobulinemic Vasculitis SP - 283086 VL - 2014 AB - Diffuse alveolar hemorrhage (DAH) is a serious complication of the small vessel vasculitis syndromes and carries a high mortality. Recombinant activated factor VII (rFVIIa) is used to treat bleeding in patients with hemophilia and antibodies to factor VIII or IX. It is increasingly being used in life-threatening hemorrhage in a variety of other settings in which conventional therapy is unsuccessful. Randomized controlled trials of rFVIIa in DAH are lacking. However, several case reports have described a complete or sustained control of DAH using rFVIIa after patients failed to respond to medical treatment. There are no case reports in the literature describing the use or the failure of rFVIIa in DAH associated with cryoglobulinemic vasculitis. We here report the failure of rFVIIa to control DAH in a patient with CD5+ B-cell non-Hodgkin’s lymphoma and cryoglobulinemic vasculitis. SN - 2090-6560 UR - https://doi.org/10.1155/2014/283086 DO - 10.1155/2014/283086 JF - Case Reports in Hematology PB - Hindawi Publishing Corporation KW - ER -