Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2014, Article ID 626831, 4 pages
http://dx.doi.org/10.1155/2014/626831
Case Report

Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient

1Department of Internal Medicine, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, Italy
2Department of Clinical Chemistry, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, Italy

Received 31 July 2014; Accepted 16 October 2014; Published 6 November 2014

Academic Editor: Kazunori Nakase

Copyright © 2014 Natale Vazzana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. W Collins, E. Chalmers, D. Hart et al., “Diagnosis and management of acquired coagulation inhibitors: a guideline from UKHCDO,” British Journal of Haematology, vol. 162, no. 6, pp. 758–773, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Huth-Kühne, F. Baudo, P. Collins et al., “International recommendations on the diagnosis and treatment of patients with acquired hemophilia A,” Haematologica, vol. 94, no. 4, pp. 566–575, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Knoebl, P. Marco, F. Baudo et al., “Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2),” Journal of Thrombosis and Haemostasis, vol. 10, no. 4, pp. 622–631, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Zucker, M. H. Zarrabi, G. S. Romano, and F. Miller, “IgM inhibitors of the contact activation phase of coagulation in chlorpromazine treated patients,” British Journal of Haematology, vol. 40, no. 3, pp. 447–457, 1978. View at Publisher · View at Google Scholar · View at Scopus
  5. M. J. Goodrick, A. G. Prentice, J. A. Copplestone, D. H. Pamphilon, and R. J. Boon, “Acquired factor XI inhibitor in chronic lymphocytic leukaemia,” Journal of Clinical Pathology, vol. 45, no. 4, pp. 352–353, 1992. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Billon, M.-T. Blouch, M. Escoffre-Barbe, C. Le Niger, A.-M. Le Roux, and J.-F. Abgrall, “A case of chronic myelomonocytic leukaemia and factor XI deficiency with a circulating anticoagulant,” Haemophilia, vol. 7, no. 4, pp. 433–436, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. D. S. Kyriakou, M. G. Alexandrakis, F. H. Passam et al., “Acquired inhibitors to coagulation factors in patients with gastrointestinal diseases,” European Journal of Gastroenterology and Hepatology, vol. 14, no. 12, pp. 1383–1387, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Ortiz Jiménez, S. Loera Fragoso, and M. Rull Gabayet, “Aquired inhibitors of coagulation in a patient with systemic lupus erythematosus and antiphospholipid antibodies: response to rituximab,” Reumatologia Clinica, vol. 4, no. 2, pp. 74–76, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Segalen, P. Siohan, L. Podeur, B. Wehbe, P. Hutin, and F. Lellouche, “Acquired factor XI inhibitor and chronic lymphocytic leukemia,” Revue de Medecine Interne, vol. 29, no. 10, pp. 832–833, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Castaman, M. Ruggeri, and F. Rodeghiero, “Acquired transitory factor XI inhibitor after gynaecological surgery,” Haemophilia, vol. 14, no. 3, pp. 643–644, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Bortoli, O. A. Monticielo, R. M. Chakr et al., “Acquired factor XI inhibitor in systemic lupus erythematosus—case report and literature review,” Seminars in Arthritis and Rheumatism, vol. 39, no. 1, pp. 61–65, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Reece, L. P. Clyne, R. Romero, and J. C. Hobbins, “Spontaneous factor XI inhibitors. Seven additional cases and a review of the literature,” Archives of Internal Medicine, vol. 144, no. 3, pp. 525–529, 1984. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Salomon, A. Zivelin, T. Livnat, and U. Seligsohn, “Inhibitors to factor XI in patients with severe factor XI deficiency,” Seminars in Hematology, vol. 43, no. 1, pp. S10–S12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Salomon, A. Zivelin, T. Livnat et al., “Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency,” Blood, vol. 101, no. 12, pp. 4783–4788, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. M. M. Bern, M. Sahud, O. Zhukov, K. Qu, and W. Mitchell Jr., “Treatment of factor XI inhibitor using recombinant activated factor VIIa,” Haemophilia, vol. 11, no. 1, pp. 20–25, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. H.-H. Chang and B.-L. Chiang, “The diagnosis and classification of autoimmune coagulopathy: an updated review,” Autoimmunity Reviews, vol. 13, no. 4-5, pp. 587–590, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. B. N. Reeves and N. S. Key, “PL-12 acquired hemophilia in malignancy,” Thrombosis Research, vol. 129, no. 1, pp. S66–S68, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Tiede, R. Eisert, A. Czwalinna, W. Miesbach, I. Scharrer, and A. Ganser, “Acquired haemophilia caused by non-haemophilic factor VIII gene variants,” Annals of Hematology, vol. 89, no. 6, pp. 607–612, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. P. H. Bolton-Maggs, “Factor XI deficiency—resolving the enigma?” Hematology, pp. 97–105, 2009. View at Google Scholar
  20. Z. Rolović, I. Elezović, B. Obrenović, and C. Rizza, “Life-threatening bleeding due to an acquired inhibitor to factor XII-XI successfully treated with “activated” prothrombin complex concentrate (FEIBA),” British Journal of Haematology, vol. 51, no. 4, article 659, 1982. View at Google Scholar · View at Scopus
  21. C. C. Hsia, M. Keeney, A. A. Bosco, and A. Xenocostas, “Treatment of acquired factor X inhibitor by plasma exchange with concomitant intravenous immunoglobulin and corticosteroids,” American Journal of Hematology, vol. 83, no. 4, pp. 318–320, 2008. View at Publisher · View at Google Scholar · View at Scopus