Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency

Table 3

Correlation between ATT phenotype and emphysema, lymphoma, and lung cancer.

Phenotype	Risk of emphysema [13]	Incidence of lymphoma [14]	Risk of lung cancer [15, 16]
MM (normal)	No increase	Baseline risk	Baseline risk
MZ	Possible mild increase	5.8%	Hypothetical increased risk
SS	No increase	0.4%
SZ	20 to 50%	n/a
ZZ	80 to 100%	n/a
Null	100% by age 30	n/a