Case Report
36-Year-Old Female with Catastrophic Antiphospholipid Syndrome Treated with Eculizumab: A Case Report and Review of Literature
Table 1
Precipitating factors and clinical manifestations of 280 patients with catastrophic APS from the CAPS registry.
| | Precipitating factors | Number of patients | (%) |
| | Infection | 62 | (22) | | Surgery | 28 | (10) | | Oral anticoagulation withdrawal/low INR | 22 | (8) | Medications
(captopril, oral contraceptives, danazol, and thiazide diuretics) [7] | 20 | (7) | | Obstetric complications | 19 | (7) | | Neoplasia | 14 | (5) | | SLE flare | 8 | (3) |
| | First clinical manifestation of the catastrophic episode | | Pulmonary involvement | 67 | (24) | | Neurological involvement | 50 | (18) | | Renal involvement | 49 | (18) | | Cutaneous involvement | 28 | (10) | | Cardiac involvement | 27 | (10) | | Adrenal involvement | 3 | (1) |
| | Organ involvement during the episode | | Kidney | 180 | (71) | | Lung | 163 | (64) | | Brain | 158 | (62) | | Heart | 131 | (51) | | Skin | 128 | (50) | | Liver | 85 | (33) | | Gastrointestinal | 60 | (25) | | Peripheral venous thrombosis | 59 | (23) | | Spleen | 48 | (19) | | Adrenal glands | 33 | (13) | | Peripheral artery thrombosis | 27 | (11) | | Pancreas | 19 | (8) | | Retina | 17 | (7) | | Peripheral nerve | 12 | (5) | | Bone marrow | 10 | (4) |
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Reproduced with permission from Cervera et al. [6].
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