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Case Reports in Hematology
Volume 2014, Article ID 785454, 3 pages
Case Report

Chronic Idiopathic Neutrophilia in Two Twins

1Pediatric Department, “Magna Graecia” University of Catanzaro, Località Germaneto, Viale Europa, 88100 Catanzaro, Italy
2Primary Pediatric Care, ASP Cosenza, Italy

Received 19 August 2014; Accepted 21 October 2014; Published 6 November 2014

Academic Editor: Salah Aref

Copyright © 2014 Roberto Miniero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neutrophilia in adults refers to an alteration in the total number of blood neutrophils that is in excess of about 7500 cells/μL. This definition is restrictive in childhood as neutrophil count is age-dependent. Chronic Idiopathic Neutrophilia (CIN) refers to a condition that persists for many years in individuals who appear otherwise healthy. CIN is rarely mentioned in scientific literature and in academic books of hematology; only few words are dedicated to this topic. We report a case study of two twins with CIN followed from the first year of life to 24 years of age. To the best of our knowledge this is the first case report of two twins with CIN followed through a long period of time. We believe that our observation may contribute to better understand and characterize this hematologic abnormality.