High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA

Figure 2

(a) Metaphase FISH: dual-color dual-fusion FISH probe has one fusion, two orange (PML) and two green (RARA) signals on representative metaphase nuclei. (b) Illustration of positions of FISH probes based on several DAPI (as in (a)) and reverse DAPI (not shown) metaphase studies confirming the complex translocation: t(9;17;15;12;15)(q34;q21;q24;q13;q26.1).

(a)

(b)