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Case Reports in Hematology
Volume 2015, Article ID 384821, 4 pages
http://dx.doi.org/10.1155/2015/384821
Case Report

Metastatic Calcinosis Cutis: A Case in a Child with Acute Pre-B Cell Lymphoblastic Leukemia

1Department of Dermatology, Hospital Central Dr. Ignacio Morones Prieto, Universidad Autónoma de San Luis Potosí, 78210 San Luis Potosí, SLP, Mexico
2Department of Pathology, Hospital Central Dr. Ignacio Morones Prieto, Universidad Autónoma de San Luis Potosí, 78210 San Luis Potosí, SLP, Mexico

Received 11 June 2015; Revised 20 July 2015; Accepted 28 July 2015

Academic Editor: Marie-Christine Kyrtsonis

Copyright © 2015 Juan Pablo Castanedo-Cázares et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC) may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis showed amorphous basophilic deposits in the dermis suggestive of calcium deposits. Laboratory tests confirmed serum hypercalcemia. Extensive investigations such as bone marrow biopsy established the diagnosis of an acute pre-B cell lymphoblastic leukemia. Hypercalcemia in hematopoietic malignancies is unusual, especially as initial manifestation of the disease. Careful review of the literature fails to reveal previous reports of these peculiar cutaneous lesions of MCC in children with leukemia.