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Case Reports in Hematology
Volume 2015, Article ID 583451, 3 pages
Case Report

Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag

1Department of Medicine, University of Arizona, Tucson, AZ 86721, USA
2Medical Oncology, Arizona Oncology Associates, Tucson, AZ 85704, USA
3Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA

Received 11 March 2015; Accepted 3 June 2015

Academic Editor: Tatsuharu Ohno

Copyright © 2015 Faiz Anwer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Severe refractory ITP is clinically challenging and a variety of single or combination chemotherapies have been tried with limited outcome. We report a case of ITP that was unresponsive to multiple agents including high-dose steroid, IVIG, Rho(D) immune globulin, rituximab, cyclosporine, azathioprine, vincristine, mycophenolate mofetil, romiplostim, and eltrombopag; however, it achieved complete remission with combination treatment of cyclophosphamide and eltrombopag.