Case Reports in Hematology / 2015 / Article / Tab 2

Case Report

Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

Table 2

VWF:FVIII concentrates validated in clinical studies involving relatively large number of VWD patients.

ConcentrateManufacturer VWF:RCo/FVIIIViral inactivationPurification methodology

Alphanate [15]Grifols (USA)1.2Solvent detergent, dry heatHeparin ligand chromatography,
Biostate [17, 31, 32]CSL Behring2.0Solvent detergent, dry heatprecipitation, and heparin ligand chromatography
Fanhdi [15, 33]Grifols (SP)1.6Solvent detergent, dry heatPrecipitation, heparin ligand chromatography
Haemate-P (Humate-P) [16, 19, 20, 26, 27]CSL Behring2.5PasteurizationPolyelectrolyte precipitation
Wilate [34]Octapharma0.8Solvent detergent, dry heatAffinity chromatography, size exclusion
Wilfactin [18, 35]LFB (Lille)60Solvent detergent, nanofiltration, and dry heatIon-exchange, affinity chromatography

Ratio of ristocetin cofactor activity (VWF:RCo) to FVIII activity expressed as IU/mL.

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