Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

Table 3

Recommended factor VWF/FVIII concentrates dosages for different indications in the treatment of VWD3 [24–26].

Indication	Dose; VWF:RCo units	Frequency of infusions	Duration of treatment	Target; VWF:RCO	Target FVIII
Major surgery		Every 8–24 hours	7–14 days	Maintain trough; >0.5 IU/dL	Maintain trough; >0.5 IU/dL
Loading	40–60 U/kg
Maintenance	20–40 U/kg
Minor surgery		Every 12–48 hours	1–5 days	Maintain trough; >0.5 IU/dL	Maintain trough; >0.5 IU/dL
Loading	30–60 U/kg
Maintenance	20–40 U/kg
Tooth extraction	20–40 U/kg	Single infusion	Single infusion	Achieve trough; >0.5 IU/dL	Achieve trough; >0.5 IU/dL
Spontaneous or traumatic bleeding	25 U/kg	Daily infusion	2–4 days	Maintain trough; >0.5 IU/dL	Maintain trough; >0.5 IU/dL