Case Reports in Hematology / 2015 / Article / Tab 3

Case Report

Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

Table 3

Recommended factor VWF/FVIII concentrates dosages for different indications in the treatment of VWD3 [2426].

Indication Dose
VWF:RCo units
Frequency of infusions Duration of treatmentTarget
VWF:RCO
Target FVIII

Major surgery Every 8–24 hours 7–14 days Maintain trough
>0.5 IU/dL
Maintain trough
>0.5 IU/dL
 Loading 40–60 U/kg
 Maintenance20–40 U/kg
Minor surgery Every 12–48 hours 1–5 days Maintain trough
>0.5 IU/dL
Maintain trough
>0.5 IU/dL
 Loading 30–60 U/kg
 Maintenance20–40 U/kg
Tooth extraction20–40 U/kgSingle infusionSingle infusionAchieve trough
>0.5 IU/dL
Achieve trough
>0.5 IU/dL
Spontaneous or traumatic bleeding25 U/kgDaily infusion 2–4 daysMaintain trough
>0.5 IU/dL
Maintain trough
>0.5 IU/dL

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