Case Report
Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease
Table 3
Recommended factor VWF/FVIII concentrates dosages for different indications in the treatment of VWD3 [
24–
26].
| Indication | Dose VWF:RCo units | Frequency of infusions | Duration of treatment | Target VWF:RCO | Target FVIII |
| Major surgery | |
Every 8–24 hours |
7–14 days |
Maintain trough >0.5 IU/dL |
Maintain trough >0.5 IU/dL | Loading | 40–60 U/kg | Maintenance | 20–40 U/kg | Minor surgery | |
Every 12–48 hours |
1–5 days |
Maintain trough >0.5 IU/dL |
Maintain trough >0.5 IU/dL | Loading | 30–60 U/kg | Maintenance | 20–40 U/kg | Tooth extraction | 20–40 U/kg | Single infusion | Single infusion | Achieve trough >0.5 IU/dL | Achieve trough >0.5 IU/dL | Spontaneous or traumatic bleeding | 25 U/kg | Daily infusion | 2–4 days | Maintain trough >0.5 IU/dL | Maintain trough >0.5 IU/dL |
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