Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature

Table 1

Clinical features of reported cases of HCL with skeletal involvement.

	Ref.	No. of cases	Type of lesions	Location	Bone marrow; infiltration	Treatment
1	Quesada et al. [4]	Four	Osteolytic lesions, severe osteoporosis, and aseptic necrosis	Femoral head	Yes	RT (), daunorubicin ()
2	Demanes et al. [29]	Two	Osteolytic lesions	Right femoral neck, upper and lower thoracic vertebrae, L2 vertebral body	Yes	RT
3	Lembersky et al. [8]	Eight	Osteolytic lesions, multiple osteoporotic vertebral; compression fractures	Axial skeleton, primarily; the proximal femur	Yes	RT, interferon-α
4	Herold et al. [9]	Two	Osteolytic lesions, pathologic fracture, compression fracture, osteoblastic lesions	Right femoral head and neck, multiple thoracic and lumbar vertebral bodies, 12th thoracic vertebra	Yes	RT
5	Snell et al. [30]	One	Pathological fracture	Femur	Yes	Surgery
6	Rosen et al. [31]	One	Osseous lesions (not osteolytic)	L-5 vertebral body, lumbar epidural lesion extending from L-3 to S-2	Yes	Cladribine
7	Spedini et al. [32]	One	Osteolytic lesion	Femoral neck	Yes	RT and interferon-α
8	Lal et al. [10]	One	Marrow-based lesions (not osteolytic)	Left femur neck, left proximal femur, and both greater trochanters	No	Cladribine
9	Karmali et al. [11]	One	Localized skeletal disease (no fracture)	Left hip involving the inferior half of the femoral head and neck	No	Cladribine
11	Present case	One	Osteolytic and osteosclerotic lesions	Axial skeleton, sacrum, pelvis, and both femurs	No	RT and cladribine

Ref.: references, No.: number, and RT: radiation therapy.