Case Report

Primary MALT Lymphoma of the Breast Treated with Definitive Radiation

Table 1

Characteristics of breast MALT lymphoma cases available in the English language with a minimum follow-up of 3 months and a reported disease status outcome.

StudyAgeTreatmentRT doseDisease statusFollow-up (months)

Gupta et al., 2000 [13]64RT44.2 Gy + R side boost up to 51 Gy NED64
Batstone et al., 2003 [14]87Palliative RT(—)Alive with disease11
Ghetu et al., 2011 [15]77Lumpectomy; whole breast irradiation following breast relapse; rituximab following breast relapse; local RT following lacrimal gland relapse(—)NED60
Tsang et al., 2001 [16]74RT for primary breast MALT and resection for Ca ampulla of Vater relapse(—)NED55
Wright et al., 1996 [17]55RT(—)NED168
Zobolas et al., 2002 [18]68Breast conservation surgery; bilateral axillary lymph node dissection; 6 cycles of CHOP and RT (RT given 6 months after surgery)(—)NED10
Bailey et al., 1996 [19]36Excision, chemotherapy, and RT(—)NED46
Rajendran et al., 2008 [20]66RT4140 cGy in 23 fractionsNED72
Matsuda et al., 2014 [21]47Mastectomy with sentinel node biopsy and radical axillary node dissectionNED6
Arslan et al., 2012 [22]69CHOP protocol-8 cyclesNED6
Michael et al., 2005 [23]592 cycles of chlorambucil + CHOP NED24
Nassif and Ozdemirli, 2013 [24]18ExcisionAlive with disease4
Huber et al., 2002 [25]328 cycles of cyclophosphamide, Oncovin, and prednisoloneNED48
Julen et al., 2009 [26]86Patey surgeryNED60
Kambouchner et al., 2003 [27]37No treatmentNED42
Kim et al., 2015 [28]55SurgeryNED9
Kuper-Hommel et al., 1999 [29]653 cycles of CHOPNED10
Mattia et al., 1993 [30]69ExcisionNED9
Mattia et al., 1993 [30]77ExcisionNED48
Mattia et al., 1993 [30]81ExcisionNED10
Mattia et al., 1993 [30]65ExcisionDeath from progressive disease25
Raderer et al., 2005 [31]594 cycles of oxaliplatinNED20
Said et al., 2013 [32]52Cyclophosphamide, steroid, and CHOPDeath from progressive disease12
Taeda et al., 2006 [33]84Mastectomy with axillary lymph node dissection and 4 cycles of rituximabNED18
Welsh et al., 2006 [34]66Lumpectomy and 30.6 Gy in 18 fractionsNED36
Anavekar et al., 2008 [35]56Surgery, postoperative RT, and tamoxifenNED24
Kuper-Hommel et al., 2003 [36](—)RT(—)Death from unrelated causes59
Kuper-Hommel et al., 2003 [36](—)SurgeryNED134
Kuper-Hommel et al., 2003 [36](—)Surgery and anthracycline-containing chemotherapy regimenNED74
Kuper-Hommel et al., 2003 [36](—)Surgery and chemotherapyNED66
Kuper-Hommel et al., 2003 [36](—)SurgeryNED16
Kuper-Hommel et al., 2003 [36](—)Surgery and anthracycline-containing chemotherapy regimenDeath from progressive disease107

SOB: shortness of breath.
CXR: chest X-ray.
NED: no evidence of disease.