Case Reports in Hematology

Case Reports in Hematology / 2016 / Article

Case Report | Open Access

Volume 2016 |Article ID 3042531 |

Vibhor Sharma, Tapas Dora, Mehul Patel, Sankalp Sancheti, Epari Sridhar, "Case Report of Diffuse Large B Cell Lymphoma of Uterine Cervix Treated at a Semiurban Cancer Centre in North India", Case Reports in Hematology, vol. 2016, Article ID 3042531, 4 pages, 2016.

Case Report of Diffuse Large B Cell Lymphoma of Uterine Cervix Treated at a Semiurban Cancer Centre in North India

Academic Editor: Massimo Gentile
Received15 Apr 2016
Revised12 Jul 2016
Accepted13 Jul 2016
Published11 Aug 2016


Lymphoma of the uterine cervix is very rare. We report a case of diffuse large B cell lymphoma (DLBCL) involving the uterine cervix treated at a newly commissioned semiurban cancer centre in north India in 2015. Data for this study was obtained from the hospital electronic medical records and the patient’s case file. We also reviewed published case reports of uterine and cervical lymphoma involving forty-one patients. We treated a case of stage IV DLBCL cervix with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) and intrathecal methotrexate followed by consolidation with radiotherapy. The patient showed complete response to chemotherapy. We conclude that, in advanced stage lymphoma involving uterus and cervix, combination of chemotherapy and radiotherapy is effective in short term.

1. Introduction

Non-Hodgkin’s Lymphoma (NHL) affects extranodal sites in one-third of cases. The most commonly affected extranodal sites are the gastrointestinal tract and skin. Rarely may female reproductive organs be involved, most commonly ovary. NHL of the cervix is extremely rare. In one series, cervix was involved in 1 out of 730 cases of NHL and 1 out of 175 cases of extranodal lymphoma [1]. It is usually a high grade B cell lymphoma [2] with abnormal vaginal bleeding as the most common presenting symptom (60%) [3]. As cervical lymphomas arise from the stroma rather than the mucosa, hence cervical cytology is not very sensitive in recognizing it. We report a case of DLBCL involving uterine cervix and provide a review of literature of cervical lymphoma.

2. Case Presentation

A 61-year-old postmenopausal lady presented with bleeding per vaginum and 6 kg weight loss in preceding 3 months. Her performance status was 1 (ECOG scale). Local examination revealed a 7 × 6 cm mass in the cervix and extending to lower uterus and upper third of vagina, involving both parametria. Rectal mucosa was uninvolved. There was no hepatosplenomegaly or lymphadenopathy. Contrast Enhanced Computed Tomography (CECT) scan of chest abdomen and pelvis revealed a 8.7 × 7.9 cm mass in cervix with extension into uterus and lower cervix, abutting the urinary bladder, laterally involving parametrium, encasing right ureter causing mild-to-moderate hydronephrosis and posteriorly loss of fat planes with rectum; bilateral external iliac lymph nodes were enlarged (largest 2.5 × 2 cm); 1.3 cm mildly enhancing mass in uncinate process of pancreas; multiple hypodense lesions in both lobes of liver, largest being 1.5 cm; and 2.8 × 2.4 cm soft tissue deposit in subcutaneous plane in right lower chest wall and multiple subcentimetric nodules in bilateral lungs (Figures 1 and 2). Bone marrow and cerebrospinal fluid were uninvolved. Cervical biopsy revealed diffuse large B cell lymphoma. On immunohistochemistry, cells tested positive for CD20, MUM 1, and BCL 6; Mib 1 proliferation index was 70–80%. Viral serology for HIV, Hepatitis B surface antigen, and Hepatitis C were negative. After complete diagnostic workup, she was diagnosed as DLBCL stage IV BEX IPI 3/5. She was treated with 6 cycles of 3-weekly R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) and intrathecal methotrexate 12 mg on day 1 of each cycle. After four cycles, response assessment CT scan showed almost total resolution of all lesions. After 6 cycles of chemotherapy, contrast enhanced CT scan showed complete response (CR) (Figures 3 and 4). After completion of the planned chemotherapy, she received involved field radiotherapy to cervix 45 Gy/25 fractions over 5 weeks. She completed her treatment in January 2016. During treatment she developed grade 1 peripheral neuropathy.

3. Discussion

NHL of the uterine cervix is a rare tumour. The most common symptoms are vaginal bleeding, vaginal discharge, and pelvic discomfort and dyspareunia [2]. Differential diagnoses of cervical lymphomas include sarcoma, poorly differentiated carcinoma, neuroendocrine tumours, malignant mixed Mullerian tumour, melanoma, extraosseous Ewing’s sarcoma, and chronic cervicitis. Most cases of NHL involving uterine cervix are stage I or II. The optimal treatment of such tumours is not clear. These tumours have been managed with chemotherapy, radiotherapy, and surgery [46], alone or in combination. In a study of twenty-six cases of NHL involving the uterus [3], there were ten cases of stage I E or II E primarily involving the uterus and twelve cases of stage III E/IV involving the uterus. The median age of presentation in the two groups was 55 years and 58 years, respectively. DLBCL accounted for 80% and 50% of cases in the two groups, respectively, the remainder being constituted by follicular lymphoma, small lymphocytic lymphoma, marginal zone B cell lymphoma, and precursor T cell lymphoblastic lymphoma. The five-year survival rates in the two groups were 83% and 29%, respectively [3]. Various chemotherapy regimens have been used for DLBCL of cervix. These include MACOP-B [2] (methotrexate, cytarabine, cyclophosphamide, vincristine, prednisolone, and bleomycin), CHOP [2, 4, 7] (cyclophosphamide, doxorubicin, vincristine, and prednisolone), BACOD [4] (bleomycin, doxorubicin, cyclophosphamide, and vincristine), R-CHOP [810] (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone), CVP [11] (cyclophosphamide, vincristine, and prednisolone), CHOP-bleo [12] (cyclophosphamide, doxorubicin, vincristine, prednisolone, and bleomycin), ASAP [12] (doxorubicin, methylprednisolone, cytarabine, and cisplatin), and CEOP [13] (cyclophosphamide, etoposide, vincristine, and prednisolone). These patients attain prolonged disease-free survival with combination of chemotherapy and radiotherapy.

4. Conclusion

NHL of uterine cervix is a rare tumour. It may be primary or secondary. It is usually high grade B cell lymphoma. Deep biopsy is required for diagnosis as surface cytology is frequently negative. Standard treatment is not established. In advanced stage disease, combination of chemotherapy and radiotherapy is the treatment of choice with encouraging early outcomes. This treatment is feasible in semiurban settings in developing countries.


Homi Bhabha Cancer Hospital is a unit of Tata Memorial Hospital, Mumbai, India

Competing Interests

The authors declare that they have no competing interests.


  1. I. Chorlton, R. F. Karnei Jr., F. M. King, and H. J. Norris, “Primary malignant reticuloendothelial disease involving the vagina, cervix, and corpus uteri,” Obstetrics & Gynecology, vol. 44, no. 5, pp. 735–748, 1974. View at: Google Scholar
  2. E. Garavaglia, G. Taccagni, S. Montoli et al., “Primary stage I–IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients,” Gynecologic Oncology, vol. 97, no. 1, pp. 214–218, 2005. View at: Publisher Site | Google Scholar
  3. R. Vang, L. Jeffrey Medeiros, C. S. Ha, and M. Deavers, “Non-Hodgkin's lymphomas involving the uterus: a clinicopathologic analysis of 26 cases,” Modern Pathology, vol. 13, no. 1, pp. 19–28, 2000. View at: Publisher Site | Google Scholar
  4. J. K. Chan, V. Loizzi, A. Magistris et al., “Clinicopathologic features of six cases of primary cervical lymphoma,” American Journal of Obstetrics and Gynecology, vol. 193, no. 3, pp. 866–872, 2005. View at: Publisher Site | Google Scholar
  5. A. Anagnostopoulos, N. Mouzakiti, S. Ruthven, J. Herod, and M. Kotsyfakis, “Primary cervical and uterine corpus lymphoma; a case report and literature review,” International Journal of Clinical and Experimental Medicine, vol. 6, no. 4, pp. 298–306, 2013. View at: Google Scholar
  6. D. S. Vasudev and A. K. Kaler, “Case report: non-Hodgkin's lymphoma of the uterine cervix,” Online Journal of Health and Allied Sciences, vol. 11, no. 1, article 13, 2012. View at: Google Scholar
  7. F. Heredia, M. Bravo, M. Pierotic, A. Majlis, and L. Carmona, “Neoadjuvant combined chemotherapy followed by external whole pelvic irradiation in two cases of primary extranodal non-Hodgkin's lymphoma of the uterine cervix,” Gynecologic Oncology, vol. 97, no. 1, pp. 285–287, 2005. View at: Publisher Site | Google Scholar
  8. G. Baijal, B. M. Vadiraja, D. J. Fernandes, and M. S. Vidyasagar, “Diffuse large B-cell lymphoma of the uterine cervix: a rare case managed novelly,” Journal of Cancer Research and Therapeutics, vol. 5, no. 2, pp. 140–142, 2009. View at: Publisher Site | Google Scholar
  9. J. Parnis, D. J. Camilleri, D. Babic, J. DeGaetano, and C. Savona-Ventura, “Lymphoma of the Cervix,” Case Reports in Hematology, vol. 2012, Article ID 326127, 4 pages, 2012. View at: Publisher Site | Google Scholar
  10. Y. José Gutiérrez, A. C. Marcuello Franco, A. Lanzón Laga, F. Puig Ferrer, C. Del Agua Arias, and R. Con de Ma, “Primary lymphoma of the uterine cervix,” Global Journal of Medical Research E: Gynecology and Obstetrics, vol. 14, no. 2, version 1.0, pp. 1–6, 2014. View at: Google Scholar
  11. N. L. Harris and R. E. Scully, “Malignant lymphoma and granulocytic sarcoma of the uterus and vagina: a clinicopathologic analysis of 27 cases,” Cancer, vol. 53, no. 11, pp. 2530–2545, 1984. View at: Publisher Site | Google Scholar
  12. E. L. Stroh, P. C. Besa, J. D. Cox, L. M. Fuller, and F. F. Cabanillas, “Treatment of patients with lymphomas of the uterus or cervix with combination chemotherapy and radiation therapy,” Cancer, vol. 75, no. 9, pp. 2392–2399, 1995. View at: Publisher Site | Google Scholar
  13. Y. Yokoyama, S. Sato, Y. H. Xiao, K. Tanaka, H. Maruyama, and Y. Saito, “Primary non-Hodgkin's lymphoma of the uterine cervix,” Archives of Gynecology and Obstetrics, vol. 265, no. 2, pp. 108–111, 2001. View at: Publisher Site | Google Scholar

Copyright © 2016 Vibhor Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related articles

No related content is available yet for this article.
 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

No related content is available yet for this article.

Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.