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Case Reports in Hematology
Volume 2016, Article ID 4158567, 4 pages
http://dx.doi.org/10.1155/2016/4158567
Case Report

A 26-Year-Old Female with Systemic Mastocytosis with Associated Myeloid Neoplasm with Eosinophilia and Abnormalities of PDGFRB, t(4;5)(q21;q33)

1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA
2The Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA

Received 17 May 2016; Revised 20 July 2016; Accepted 7 August 2016

Academic Editor: Ramon Tiu

Copyright © 2016 Laura E. Brown et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Gallagher, D. E. Horsman, P. Tsang, and D. L. Forrest, “Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders,” Cancer Genetics and Cytogenetics, vol. 181, no. 1, pp. 46–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Savage, T. I. George, and J. Gotlib, “Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, and FGFR1: a review,” International Journal of Laboratory Hematology, vol. 35, no. 5, pp. 491–500, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. E. J. Baxter, S. Kulkarni, J.-L. Vizmanos et al., “Novel translocations that disrupt the platelet-derived growth factor receptor β (PDGFRB) gene in BCR–ABL-negative chronic myeloproliferative disorders,” British Journal of Haematology, vol. 120, no. 2, pp. 251–256, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Pardanani, “Systemic mastocytosis in adults: 2013 update on diagnosis, risk stratification, and management,” American Journal of Hematology, vol. 88, no. 7, pp. 612–624, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. M. M. Stoecker and E. Wang, “Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review,” Archives of Pathology and Laboratory Medicine, vol. 136, no. 7, pp. 832–838, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Walz, G. Metzgeroth, C. Haferlach et al., “Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene,” Haematologica, vol. 92, no. 2, pp. 163–169, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. I. Lahortiga, C. Akin, J. Cools et al., “Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion,” Haematologica, vol. 93, no. 1, pp. 49–56, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Vega-Ruiz, J. E. Cortes, M. Sever et al., “Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis,” Leukemia Research, vol. 33, no. 11, pp. 1481–1484, 2009. View at Publisher · View at Google Scholar
  9. S. Ørstavik, R. Solberg, K. Taskén et al., “Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase,” Biochemical and Biophysical Research Communications, vol. 220, no. 3, pp. 759–765, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Pfeifer, A. Aszódi, U. Seidler, P. Ruth, F. Hofmann, and R. Fässler, “Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II,” Science, vol. 274, no. 5295, pp. 2082–2086, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Yamada and J. A. Cancelas, “FIP1L1/PDGFRα-associated systemic mastocytosis,” International Archives of Allergy and Immunology, vol. 152, no. 1, pp. 101–105, 2010. View at Publisher · View at Google Scholar · View at Scopus