Case Report

Balancing Therapy with Thrombopoietin Receptor Agonists and Splenectomy in Refractory Immune Thrombocytopenic Purpura: A Case of Postsplenectomy Thrombocytosis Requiring Plateletpheresis

Table 1

Case reports of thrombocytosis following splenectomy for refractory ITP treated with TPO-RA preoperatively.

PatientTPO receptor agonistPlatelets before splenectomy
(109/L)
Maximum platelets after splenectomy
(109/L)
InterventionPostintervention platelet count
(109/L)

Our caseRomiplostim
8 days earlier
551767Apheresis
hydroxyurea
425
Baldini et al. [21]Romiplostim
date not reported
55740None198
(at 3 months)
Sivera et al. [22]Romiplostim
5 days earlier
1291013NoneNormalized at 2 months
Raval et al. [23]Romiplostim
22 hours earlier
642058
1096
Apheresis 2
hydroxyurea
522
324