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Case Reports in Hematology
Volume 2017 (2017), Article ID 1950724, 4 pages
https://doi.org/10.1155/2017/1950724
Case Report

Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review

1Department of Hematology and Oncology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
2Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
3Endocrinology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
4Department of Pathology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA

Correspondence should be addressed to E. Chang; ude.mcb@ceniale

Received 1 November 2016; Accepted 14 December 2016; Published 4 January 2017

Academic Editor: Yusuke Shiozawa

Copyright © 2017 E. Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gelatinous marrow transformation (GMT) is a rare condition observed in severe illness or malnutrition, in which the bone marrow contains amorphous “gelatinous” extracellular material, and histopathology demonstrates varied degrees of fat cell atrophy and loss of hematopoietic elements. An association of GMT with imatinib use in chronic myeloid leukemia (CML) has been reported recently. The objective of this study is to describe a case of GMT associated with imatinib use and review the existing similar cases in the literature to identify epidemiological patterns and potential imatinib-induced mechanisms leading to gelatinous conversion.