Case Report

Waldenstrom’s Macroglobulinemia: A Report of Two Cases, One with Severe Retinopathy and One with Renal Failure

Figure 4

Histopathology findings of the biopsied tissue of the right kidney of Case 2. (a) Light microscopy revealed tubulointerstitial nephritis with marked infiltration by lymphoplasmacytic lymphoma (LPL) cells that were diffusely positive for CD20 (G: glomerulus; T: tubules; original magnification, ×100). (b) Electron microscopy showed that the renal tissue was infiltrated by LPL cells (original magnification, ×1,000). (c) Fluorescence microscopy revealed dot-like IgM depositions in the mesangial region (there were no depositions for IgG, IgA, or C3c). Significant morphological glomerular changes were not noted (photos not shown).