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Case Reports in Hematology
Volume 2017, Article ID 4531858, 4 pages
Case Report

Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction

1Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
2College of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
3Division of Hematology and Oncology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA

Correspondence should be addressed to Joselle Cook; ude.etatsnwod@kooc.ellesoj

Received 18 March 2017; Accepted 4 June 2017; Published 6 July 2017

Academic Editor: Marie-Christine Kyrtsonis

Copyright © 2017 Joselle Cook et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Extramedullary plasmacytomas (EMPs) are defined by the presence of clonal plasma cell proliferation outside of the bone marrow, portending an overall poor prognosis. This case highlights extramedullary plasmacytomas as an unusual presenting manifestation of multiple myeloma. Through incidental discovery during a delayed hemolytic transfusion reaction workup, EMPs were found in the liver, spleen, and possibly the lung. Though rare at presentation, this case emphasizes that the presence of EMPs should be considered at the outset as it not only impacts the treatment regimen for such patients but also considerably affects prognosis.