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Case Reports in Hematology
Volume 2017 (2017), Article ID 4984951, 6 pages
Case Report

A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry

1Division of Hematology, Niguarda Ca’ Granda Hospital, Milan, Italy
2Department of Laboratory Medicine, Niguarda Ca’ Granda Hospital, Milan, Italy

Correspondence should be addressed to Martina Pennisi

Received 7 November 2016; Revised 6 February 2017; Accepted 20 February 2017; Published 20 March 2017

Academic Editor: Yusuke Shiozawa

Copyright © 2017 Martina Pennisi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive clinical course and poor prognosis. Diagnosis is based on detection of CD4+ CD56+, , TCL-1+, and blood dendritic cell antigen-2/CD303+ blasts, together with the absence of lineage specific antigens on tumour cells. In this report we present a case of BPDCN presenting with extramedullary and bone marrow involvement, extensively studied by flow cytometry and immunohistochemistry, who achieved complete remission after acute lymphoblastic leukemia like chemotherapy and allogeneic hematopoietic stem cell transplantation.