Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia

Table 1

Case	Age/sex	WBC	Hemoglobin; (g/dL)	Platelets; (K/uL)	AMC(uL)	Bone marrow blast (%)	WHO	Cytogenetic	Treatment	Outcome^±	Time to AML(months)	Ref.
1	49/F	6.5	8.2	425	585	0	MDS	46,XX,t(9;22)(q34;q11)	BSC	AML	32	[2]
2	70/F	6.4	9.5	316	384	NA	MDS	46,XX/46,XX,t(9q;22q)	NA	Alive at 45 m		[3]
3	74/M; (Case)	5.3	8.3	341	1080	0	RCMD^+	44, XY, t (9:22) , 46,XY	TKI	(alive); 7 months after diagnosis
4	59/M	1.3	9.2	78	78	0	MDS	46,XY,t(9;22)(q34;q11)	TKI^+ + allo- stem cell transplant	(alive)	4	[4]
5	66/F	0.9	4.4	52	54	2	RCUD^+++	46,XX,+8,t(9; 22;16)(q34;q11.2;q23)/4; 6,XX,idem,der(12)t(12;17); (p11.2;q11.2)/46, XX .	Melphalan	(died); Developed skin Granulocytic sarcoma.	9	[4]
6	67/M	2.7	10.4	52	81	4	RCMD	45, XY,+3,-5,-7,-7,-; 20,+mar,+mar/45,XY,+3,-; 4,-8,-9,-11,-18,-20,-21,-; 21,+mar,+mar,+mar,+mar,; +mar,+breaks.; FISH t(9;22)	TKI	(died); 1 year after diagnosis developed Fungal Pneumonia		[5]
7	62/M	1.8	11.9	3	NA	5	RAEB-1	45,XY,-5,-7,+8, - 12, - 16,-; 22, + marE[?del(11)(q11)],; + marC[?der(11)t(?;11;22)],; + del(22)(q11)	BSC	(died)	2	[6]
8	67/F	3.4	11.5	111	NA	10	RAEB-2	46 XX, t(9;22)	TKI	(alive)	7	[7]
9	69/M	5.3	8.1	77	106	14	RAEB-2	45,XY,-5,-7,+8, - 12, - 16,-; 22, + marE[?del(11)(q11)],; + marC[?der(11)t(?;11;22)],; + del(22)(q11)	AraC+Mitho-xanthrone+; Tenoposide	(died); Septicemia 5 months after diagnosis.		[8]
10	64/M	6.9	7.8	98	69	16	RAEB-2	46,XY/47,XY,; +8,t(9;22)(q34;q11)	Hydroxyurea	(died)	9	[8]

WBC = white blood cell count; AMC = absolute monocyte count; WHO = World Health Organization; ^±outcome reported at the time of publication; AML acute myelogenous leukemia; BSC = best supportive care; ⁺⁺TKI = tyrosine kinase inhibitor; patient was diagnosed in April 2001. He received Imatinib for 2 months until August 2001. Given AML transformation, BMT was performed and remained alive by the time of publication in June 2003; ⁺RCMD = refractory cytopenia multilineage dysplasia; ⁺⁺⁺RCUD = refractory cytopenia multilineage dysplasia; RAEB = refractory anemia excess of blast.