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Case Reports in Hematology
Volume 2017, Article ID 6971027, 5 pages
Case Report

A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature

1Department of Medicine, Reading Hospital, West Reading, PA, USA
2Department of Anesthesiology, Mayo Clinic Hospital, Rochester, MN, USA

Correspondence should be addressed to Abdullateef Abdulkareem; gro.htlaehgnidaer@meerakludba.oyad

Received 13 July 2017; Accepted 22 August 2017; Published 26 September 2017

Academic Editor: Marie-Christine Kyrtsonis

Copyright © 2017 Abdullateef Abdulkareem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.