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Case Reports in Hematology
Volume 2017 (2017), Article ID 7815095, 4 pages
https://doi.org/10.1155/2017/7815095
Case Report

Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma

1Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA
2Department of Pathology, University of Florida, Gainesville, FL, USA

Correspondence should be addressed to Prajwol Pathak

Received 5 October 2016; Accepted 24 January 2017; Published 8 February 2017

Academic Editor: Tatsuharu Ohno

Copyright © 2017 Prajwol Pathak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic myeloid leukemia (CML) and mantle cell lymphoma (MCL) are hematologic malignancies that originate from different oligopotent progenitor stem cells, namely, common myeloid and lymphoid progenitor cells, respectively. Although blastic transformation of CML can occur in the lymphoid lineage and CML has been related to non-Hodgkin lymphoma on transformation, to our knowledge, de novo and synchronous occurrence of CML and MCL has not been reported. Herein, we report the first case of synchronous CML and MCL in an otherwise healthy 38-year-old man. Potential etiologies and pathological relationships between the two malignancies are explored, including the possibility that the downstream effects of BCR-ABL may link it to an overexpression of cyclin D1, which is inherent to the etiology of MCL.