Case Report

Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature

Table 1

Family History of venous thromboembolic events of the index case.

RelationshipAge at diagnosisType of AT deficiencyOther inherited or acquired risk factorsHistory of VTEManagementOutcome

Mother501SmokingDVT-PEN/AVTE resolved

Sister 1181Postpartum at time of deathFatal PEN/AFatal

Sister 2251Pregnant at time of VTECerebral vein thrombosisLMWH + AT concentrateVTE resolved, successful delivery at 34 weeks

Index case221NoneDVT & PE at age of 25
Warfarin until age of 36
Developed amaurosis fugax, switched to rivaroxaban
DVT during pregnancy at age 37Initially on tinzaparin (for pregnancy) but switched to dalteparin and AT concentrateMiscarriage at GW 7, received D & C after which continued warfarin and AT concentrate × 6 weeks

AT: antithrombin, D & C: dilatation and curettage, DVT: deep vein thrombosis, gw: gestational week, LMWH: low molecular weight heparin, and PE: pulmonary embolus.